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WHO FOOD ADDITIVES SERIES: 48

SAFETY EVALUATION OF CERTAIN
FOOD ADDITIVES AND CONTAMINANTS

ANNEX 2

ABBREVIATIONS USED IN THE MONOGRAPHS

ADI

acceptable daily intake

Ah

aryl hydrocarbon

AOAC

Association of Official Analytical Chemists

AUC

area under the curve of concentration–time

BrdU

bromodeoxyuridine

bw

body weight

CALUX

chemical-activated luciferase gene expression

CAS

Chemical Abstracts Service

CCFAC

Codex Committee on Food Additives and Contaminants

CGTase

cyclodextrin glucosyltransferase

CI

confidence interval

CoA

coenzyme A

CYP

cytochrome P450

DATEM

diacetyltartaric and fatty acid esters of glycerol

DTH

delayed-type hypersensitivity

EC50

median effective concentration

ED50

median effective dose

EGF

epidermal growth factor

EHMI

equivalent human monthly intake

EPA

Environmental Protection Agency (USA)

EROD

ethoxyresorufin O-deethylase

F

female

FAO

Food and Agricultural Organization of the United Nations

GC

gas chromatography

GLP

good laboratory practice

GSD

geometric standard deviation

GSFA

General Standard for Food Additives

HpCB

heptachlorobiphenyl

HpCDD

heptachlorodibenzodioxin

HpCDF

heptachlorodibenzofuran

HPLC

high-performance liquid chromatography

HxCB

hexachlorobiphenyl

HxCDD

hexachlorodibenzodioxin

HxCDF

hexachlorodibenzofuran

IARC

International Agency for Research on Cancer

IL

interleukin

IPCS

International Programme on Chemical Safety

IUPAC

International Union of Pure and Applied Chemistry

JECFA

Joint FAO/WHO Expert Committee on Food Additives

LD50

median lethal dose

LOD

limit of detection

LOEL

lowest-observed-effect level

LOQ

limit of quantification

M

male

MAFF

Ministry of Agriculture, Fisheries and Food

MeIQx

2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

MHC

major histocompatibility complex

MIC

minimum inhibitory concentration

MNNG

N-methyl--nitro-N-nitrosoguanidine

MNU

N-methyl-N-nitrosourea

MROD

methoxyresorufin O-deethylase

MS

mass spectrometry

MTD

maximum tolerated dose

NOEL

no-observed-effect level

NR

not reported

OCDD

octachlorodibenzodioxin

OCDF

octachlorodibenzofuran

PCB

polychlorinated biphenyl

PCDD

polychlorinated dibenzodioxin

PCDF

polychlorinated dibenzofuran

PCNA

proliferating cell nuclear antigen

PeCB

pentachlorobiphenyl

PeCDD

pentachlorodibenzodioxin

PeCDF

pentachlorodibenzofuran

Pi

inorganic phosphate

Pow

octanol:water partition coefficient

ppm

parts per million

PTDI

provisional tolerable daily intake

PTMI

provisional tolerable monthly intake

PTWI

provisional tolerable weekly intake

S9

9000 x g supernatant of rat liver

SD

standard deviation

SMR

standardized mortality ratio

SRBC

sheep red blood cells

T3

tri-iodothyronine

T4

thyroxine

TCDD

2,3,7,8-tetrachloro-para-dibenzodioxin

TCB

tetrachlorinated biphenyl

TCDF

tetrachlorodibenzofuran

TDI

tolerable daily intake

TEF

toxic equivalents factor

TGF

transforming growth factor

TSH

thyroid-stimulating hormone

UGT1

uridine diphosphate glucuronosyl transferase

vs

versus

WHO

World Health Organization




















    See Also:
       Toxicological Abbreviations