WHO FOOD ADDITIVES SERIES: 49
Prepared by the fifty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
The summaries and evaluations contained in this book are, in most cases, based on unpublished proprietary data submitted for the purpose of the JECFA assessment. A registration authority should not grant a registration on the basis of an evaluation unless it has first received authorization for such use from the owner who submitted the data for JECFA review or has received the data on which the summaries are based, either from the owner of the data or from a second party that has obtained permission from the owner of the data for this purpose.
World Health Organization, Geneva, 2002
IPCS—International Programme on Chemical Safety
This publication is a contribution to the International Programme on Chemical Safety.
The International Programme on Chemical Safety (IPCS), established in 1980, is a joint venture of the United Nations Environment Programme (UNEP), the International Labour Organisation (ILO), and the World Health Organization (WHO). The overall objectives of the IPCS are to establish the scientific basis for assessing the risk to human health and the environment from exposure to chemicals, through international peer-review processes, as a prerequisite for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound management of chemicals.
The Inter-Organization Programme for the Sound Management of Chemicals (IOMC) was established in 1995 by UNEP, ILO, the Food and Agriculture Organization of the United Nations, WHO, the United Nations Industrial Development Organization, and the Organisation for Economic Co-operation and Development (Partici-pating Organizations), following recommendations made by the 1992 United Nations Conference on Environment and Development to strengthen cooperation and increase coordination in the field of chemical safety. The purpose of the IOMC is to promote coordination of the policies and activities pursued by the Participating Organiza-tions, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment.
The summaries and evaluations contained in this book are, in most cases, based on unpublished proprietary data submitted for the purpose of the JMPR assessment. A registration authority should not grant a registration on the basis of an evaluation unless it has first received authorization for such use from the owner who submitted the data for JMPR review or has received the data on which the summaries are based, either from the owner of the data or from a second party that has obtained permission from the owner of the data for this purpose.
WHO Library Cataloguing-in-Publication Data
Toxicological evaluation of certain veterinary drug residues in food / prepared by the fifty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
(WHO food additives series ; 49)
1.Drug residues - toxicity 2.Ivermectin - analogs and derivatives
3.Ivermectin - toxicology 4.Tiabendazole - toxicology 5.Cefuroxime – toxicology
6. Veterinary drugs - toxicology 7.Food contamination 8.Risk assessment
I. Joint FAO/WHO Expert Committee on Food
Additives. Meeting (58th : 2002 : Rome, Italy) II.Series
ISBN 92 4 166049 X (NLM classification: WA 712)
The monographs contained in this volume were prepared at the fifty-eighth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met at FAO Headquarters in Rome, Italy, 21–27 February 2002. These monographs summarize data on the safety of residues in food of selected veterinary drugs reviewed by the Committee.
The fifty-eighth report of JECFA will be published by the World Health Organization in the WHO Technical Report Series. Reports and other documents resulting from previous meetings of JECFA are listed in Annex 1. Abbreviations used in the monographs are listed in Annex 2. The participants in the meeting are listed in Annex 3 of the present publication.
JECFA serves as a scientific advisory body to FAO, WHO, their Member States, and the Codex Alimentarius Commission, primarily through the Codex Committee on Food Additives and Contaminants and the Codex Committee on Residues of Veterinary Drugs in Foods, regarding the safety of food additives, residues of veterinary drugs, naturally occurring toxicants, and contaminants in food. Commit-tees accomplish this task by preparing reports of their meetings and publishing specifications or residue monographs and toxicological monographs on substances that they have considered.
The monographs contained in this volume are based on working papers that were prepared by working groups before the meeting. A special acknowledgement is given at the beginning of each monograph to those who prepared these working papers. The monographs were edited by E. Heseltine, Lajarthe, 24290 St Léon-sur-Vézère, France.
The preparation and editing of the monographs included in this volume were made possible through the technical and financial contributions of the Participating Organizations of the International Programme on Chemical Safety (IPCS), which supports the activities of JECFA.
The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the organizations participating in the IPCS concerning the legal status of any country, territory, city, or area or its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by those organizations in preference to others of a similar nature that are not mentioned.
Any comments or new information on the biological or toxicological properties of the compounds evaluated in this publication should be addressed to: Joint WHO Secretary of the Joint FAO/WHO Expert Committee on Food Additives, International Programme on Chemical Safety, World Health Organization, Avenue Appia, 1211 Geneva 27, Switzerland.
See Also: Toxicological Abbreviations