1967 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD
The content of this document is the result of the deliberations of the
Joint Meeting of the FAO Working Party of Experts and the WHO Expert
Committee on Pesticide Residues, which met in Rome, 4 - 11 December,
1967. (FAO/WHO, 1968)
FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS
WORLD HEALTH ORGANIZATION
This pesticide was evaluated by the 1966 Joint Meeting of the FAO
Working Party and the WHO Expert Committee on Pesticide Residues
(FAO/WHO, 1967). No additional data were considered on this compound
in 1967 but the "Comments" and "TOXICOLOGICAL EVALUATION" have been
slightly amended to read as follows:
Diphenyl appears to have been studied mostly in dogs and rats, and
special aspects have been investigated in other species. Long-term
studies have been carried out only in rats. The suspicion of
carcinogenicity raised by a study carried out under inadequate
conditions was not confirmed in later reports. In vivo and in
vitro studies in several species including man, reveal a common
detoxification mechanism. Information on possible chemical changes
undergone by diphenyl on the fruit is desired.
Specifications are now available on request.
Level causing no toxicological effect
Rat : 500 ppm in the diet, equivalent to 25 mg/kg/day
Dog : 25 mg/kg/day
Monkey : 50 mg/kg/day
Estimate of acceptable daily intake for man
Since children and ill people may consume a large amount of citrus
fruit, a higher safety factor than usual has been used.
0-0.125 mg/kg body weight.
REFERENCES PERTINENT TO EVALUATION FOR ACCEPTABLE DAILY INTAKE
FAO/WHO. (1967) FAO, PL: CP/15; WHO/Food Add./67.32