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    AGP:1970/M/12/1

    WHO/FOOD ADD/71.42

    1970 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    Issued jointly by FAO and WHO

    The content of this document is the result of the deliberations of the
    Joint Meeting of the FAO Working Party of Experts and the WHO Expert
    Group on Pesticide Residues, which met in Rome, 9-16 November, 1970.

    FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS

    WORLD HEALTH ORGANIZATION

    Rome, 1971

    This document contains summaries of data considered by the Joint
    Meeting of the FAO Working Party of Experts and the WHO Expert Group
    on Pesticide Residues in arriving at recommendations for acceptable
    daily intakes, tolerances and methods of analysis.

    A summary Report of the 1970 Joint Meeting 1/ has also been
    published which contains general considerations, including the
    principles adopted for the evaluations and a summary of the results of
    evaluations of a number of pesticide residues.

                   
    1/ Pesticide residues in food. Report of the 1970 Joint Meeting of
    the FAO Working Party of experts on pesticide residues and the WHO
    Expert Group on pesticide residues, WHO Technical Report Series, No.
    474, FAO Agricultural Studies, No. 87.

    CONTENTS

    List of Attendees

    Introduction

    The Monographs

    Carbaryl *

    Chlordane *

    Chlormequat

    2, 4 - D

    Diazinon *

    Dichlorvos *

    Dicofol *

    Dieldrin *

    Dimethoate *

    Diquat

    Dithiocarbamate Fungicides *

    Endrin *

    Ethion *

    Fentin Compounds

    Heptachlor *

    Malathion *

    Mancozeb

    Paraquat

    Parathion *

    Pyrethrins *

    2, 4, 5 - T

    Thiabendazole

    Tricyclohexyltin Hydroxide

    Appendix I     -    Index to documentation and summary of
                        recommendations concerning acceptable daily
                        intakes, tolerances, and practical residue limits,
                        as of December 1970

    Appendix II    -    References

    Appendix III   -    Glossary 563


    * Addendum
    

    LIST OF ATTENDEES

    Members of the FAO Working Party of Experts on Pesticide Residues:

    Dr D. C. Abbott, Pesticides and Toxic Gases Division, laboratory of
    the Government Chemist, London, England

    Dr K. R. Hill, Agricultural Research Service, Entomology Research
    Division, US Department of Agriculture, Beltsville, Md., USA

    Dr A. H. M. Kirby, East Malling Research Station, East Malling, Kent,
    England

    Dr P. E. Koivistoinen, Director of Food Chemistry Division, University
    of Helsinki, Finland

    Mr J. T. Snelson, Pesticide Coordinator, Department of Primary
    Industry, Canberra, A.C.T., Australia (Rapporteur)

    Dr E. Y. Spencer, Director, Research Institute, Canada Department of
    Agriculture, London, Ontario, Canada (Vice-Chairman)

    Members of the WHO Expert Committee on Pesticide Residues:

    Dr W. F. Almeida, Director, Division of Animal Biology, Biological
    Institute, Sao Paulo, Brazil

    Dr V. Benes, Chief, Department of Toxicology and Reference Laboratory,
    Institute of Hygiene, Prague, Czechoslovakia

    Professor F. Coulston, Director, Institute of Experimental Pathology
    and Toxicology, The Albany Medical College of Union University,
    Albany, N.Y., USA (Chairman)

    Dr Y. Omori, Head, Department of Pharmacology, National Institute of
    Hygienic Sciences, Setagaya, Tokyo, Japan

    Dr E. Poulsen, Director, Institute of Toxicology, National Food
    Institute, Soborg, Denmark

    Dr F. J. C. Roe, Head, Department of Experimental Pathology, Chester
    Beatty Research Institute, Institute of Cancer Research, Royal Cancer
    Hospital, London, England (Rapporteur)

    Dr H. G. Verschuuren, Head, Department of Biological Toxicology,
    National Institute of Public Health, Bilthoven, Netherlands

    Secretariat:

    Dr R. L. Baron, Chief, Biochemistry and Metabolism Section, Bureau of
    Foods and Pesticides, Food and Drug Administration Washington, D.C.,
    USA (Consultant)

    Dr P. E. Berteau, Scientist, Food Additives, WHO, Geneva, Switzerland

    Dr F. C. Lu, Chief Scientist, Food Additives, WHO, Geneva, Switzerland
    (Joint Secretary)

    Dr L. Tomatis, Chief, Chemical Carcinogenesis Unit, International
    Agency for Research on Cancer, Lyons, France

    Professor R. Truhaut, Director, Toxicological Research Centre, Faculty
    of Pharmacy, University of Paris, France (Consultant)

    Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
    Rome, Italy (Joint Secretary)

    Dr F. W. Whittemore, Senior Officer, Plant Protection Service, FAO,
    Rome, Italy

    Dr F. P. W. Winteringham, Head, Pesticide Residues and Pollution
    Section, Joint FAO/IAEA Division of Atomic Energy in Agriculture,
    Vienna, Austria

    INTRODUCTION

    A Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Committee on Pesticide Residues was held
    in Rome in November, 1970. The general considerations including the
    principles adopted for the evaluations and a summary of the results of
    evaluations on a number of pesticide residues, appear in the
    publication, "Report of the 1970 Joint Meeting of the FAO Working
    Party of Experts on Pesticide Residues and the WHO Experts Committee
    on Pesticide Residues". 1/ Additional information, including
    previously unpublished summaries of data considered by the Joint
    Meeting in arriving at recommendations for acceptable daily intakes,
    tolerances and methods of analysis, is to be found in this document.

    Many of the compounds considered at this meeting have been previously
    evaluated in earlier publications. If only a limited amount of
    additional information on these compounds has become available in the
    intervening years, only this latter information is summarized in the
    pertinent monograph, and reference is made to the previously published
    evaluation, which should also be consulted by the reader who wishes to
    obtain a complete evaluation of the compound. Such monograph addenda
    are indicated by an asterisk in the "Contents", p. iii. If a large
    amount of data has become available since the previously published
    evaluation or if the compound was first considered by the Joint
    Meeting in 1970, the pertinent monograph is reproduced in its
    entirety.

    As much relevant information as possible has been included in the
    monographs. This has been obtained from the published literature
    wherever possible, but other sources of information have also been
    used. Early and complete publication of the results of research in
    this field is very important particularly of that part which could
    form the basis for estimation of acceptable daily intakes and
    appropriate tolerances.

    Publication allows the research to be scrutinized and criticized by
    scientists from disciplines not necessarily represented at the
    meeting. Data contained in unpublished reports, because they may
    include more detail than published work, are often acceptable,
    However, such reports must be complete and nonconfidential and
    indicate authorship.

                   
    1/ Pesticide residues in food. Report of the 1970 Joint Meeting of
    the FAO Working Party of Experts on Pesticide Residues and the WHO
    Expert Group on Pesticide Residues, WHO Technical Report Series No.
    474, FAO Agricultural Studies No. 87.

    Three appendixes have been included at the end of this series of
    monographs. Appendix I is a reproduction of Appendix I in the Report 
    of the 1970 Joint Meeting, 2/ and gives the source of all the 
    previous monographs of various compounds. Appendix II gives relevant
    bibliographic data, Appendix III comprises definitions of terms, which
    were included in the Report of the 1969 Joint Meeting. 3/

    NOTE TO THE READER

    Any comments on residues in food and their evaluation should be
    addressed to:

    Plant Protection Service

    Plant Production and Protection Division

    Food and Agriculture Organization

    Rome, Italy

    Any comments on evaluation for acceptable daily intakes should be
    addressed to:

    Food Additives Unit

    World Health Organization

    Geneva, Switzerland

                   
    2/ Pesticide residues in food. Report of the 1970 Joint Meeting of
    the FAO Working Party of Experts on Pesticide Residues and the WHO
    Expert Group on Pesticide Residues, WHO Technical Report Series, No.
    474, FAO Agricultural Studies, No. 87.

    3/ Report of the 1969 Joint Meeting of the FAO Working Party of
    Experts on Pesticide Residues and the WHO Expert Group on Pesticide
    Residues, FAO Agricultural Studies, No. 84, WHO Technical Report
    Series, No. 458.





















    See Also:
       Toxicological Abbreviations