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    WHO Pesticide Residues Series, No. 3

    1973 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    The evaluations contained in these monographs were prepared by the
    Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Committee on Pesticide Residues that met
    in Geneva from 26 November to 5 December 1973.

    World Health Organization
    Geneva
    1974

              

    1  Pesticide Residues in Food: Report of the 1973 Joint Meeting of
    the FAO Working Party of Experts on Pesticide Residues and the WHO
    Expert Committee on Pesticide Residues, Wld Hlth Org. techn. Rep.
    Ser., 1974, No. 545: FAO Agricultural Studies, 1974, No. 92.

    These monographs are also issued by the Food and Agriculture
    Organization of the United Nations, Rome, as document
    FAO/AGP/1973/M/9/1.

    ISBN 92 4 166503 3

    (C) FAO and WHO 1974

    CONTENTS

    List of attendees

    Introduction

    The Monographs:

    Azinphos-ethyl

    Azinphos-methyl*

    Benomyl

    BHC (technical)*

    Bromopropylate

    Camphechlor* (Toxaphene)

    Captafol*

    Captan*

    Carbaryl*

    Carbendazim

    Demeton-S-methyl and related compounds

    Disulfoton

    Folpet*

    Formothion*

    Hexachlorobenzene (HCB)*

    Lindane*

    Malathion*

    Propoxur

    Quintozene*

    Thiometon

    Thiophanate-methyl


    Tricyclohexyltin hydroxide*

    Vamidothion
    
    ANNEX I.       RECOMMENDATIONS CONCERNING ACCEPTABLE DAILY
                   INTAKES AND RESIDUE LIMITS MADE AT THE 1973 MEETING     


    ANNEX II.      REFERENCES

    Index

              

    * Addendum.

    

    LIST OF ATTENDEES

    Members of the FAO Working Party of Experts on Pesticide Residues

    Mr A. Ambrus, Acting Department Head, Central Plant Protection and
    Quarantine Laboratory, Analytical Department of Pesticides, Budapest,
    Hungary

    Dr A. F. H. Besemer, Head, Pesticides Division, Plant Protection
    Service, Ministry of Agriculture, Wageningen, Netherlands

    Mr F. Bro-Rasmussen, Head, Department of Pesticides, Food Additives
    and Contaminants, National Food Institute, Holte, Denmark

    Dr K. Glogowski, Deputy Director (Scientific), Plant Protection
    Institute, Poznan, Poland

    Dr K. R. Hill, Chief, Analytical Chemistry Laboratory, Agricultural
    Environmental Quality Institute - ARS, Beltsville, Md, USA
    (Vice-Chairman)

    Mr J. T. Snelson, Pesticides Co-ordinator, Department of Primary
    Industry, Canberra, Australia (Rapporteur)

    Observer invited by FAO

    Mr A. J. Pieters, Chairman, Codex Committee on Pesticide Residues

    Members of the WHO Expert Committee on Pesticide Residues

    Dr G. V. Graceva, All-Union Research Institute for Hygiene and
    Toxicology of Pesticides and Polymers, Kiev, Ukrainian SSR

    Dr F. P. Kalojanova-Simeonova, Professor of Toxicology, Director,
    Research Institute of Hygiene and Occupational Health, Sofia, Bulgaria

    Dr S. D. Murphy, Associate Professor of Toxicology, Harvard
    University, School of Public Health, Boston, Mass., USA (Chairman)

    Professor I. Nir, Director, Department of Clinical Pharmacology,
    Ministry of Health, Jerusalem, Israel (Rapporteur)

    Professor F. K. Ohnesorge, Head, Department of Toxicology, Institute
    of Pharmacology, University of Kiel, Federal Republic of Germany

    Dr E. Poulsen, Director, Institute of Toxicology, National Food
    Institute, Soborg, Denmark

    Dr F. J. C. Roe, Member of the Institute of Cancer Research, London,
    England

    Professor A. H. Sundwall, Department of Pharmacology, University of
    Uppsala, Sweden

    Secretariat

    Dr R. L. Baron, Environmental Protection Agency, Pesticide and Toxic
    Substances Effects Laboratory, Research Triangle Park, N.C., USA
    (Temporary Adviser)

    Mr J. Cummings, Chief, Chemistry Branch, Registration Division, Office
    of Pesticide Programmes, US Environmental Protection Agency,
    Washington, DC., USA (Consultant)

    Dr H. Falk, Environmental Pollution, WHO, Geneva, Switzerland

    Dr F. C. Lu, Chief Scientist, Food Additives, WHO, Geneva, Switzerland
    (Joint Secretary)

    Mr A. F. Machin, Senior Research Officer, Central Veterinary
    Laboratory, Ministry of Agriculture, Weybridge, Surrey, England
    (Consultant)

    Dr M. Sharratt, Senior Medical Officer, Department of Health and
    Social Security, London, England (Temporary Adviser)

    Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
    Rome, Italy (Joint Secretary)

    Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland

    INTRODUCTION

         A Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Committee on Pesticide Residues was held
    in Geneva from 26 November to 5 December 1973. The general
    considerations, including the principles adopted for the evaluations
    and a summary of the results of evaluations on a number of pesticide
    residues, appear in the publication, "Report of the 1973 Joint Meeting
    of the FAO Working Party of Experts on Pesticide Residues and the WHO
    Expert Committee on Pesticide Residues".1 Additional information,
    including previously unpublished summaries of data considered by the
    Joint Meeting in arriving at recommendations for acceptable daily
    intakes, tolerances and methods of analysis, is to be found in this
    document.

         Many of the compounds considered at this meeting have been
    previously evaluated in earlier publications. If only a limited amount
    of additional information on these compounds has become available in
    the intervening years, only this latter information is summarized in
    the pertinent monograph, and reference is made to the previously
    published evaluation, which should also be consulted by the reader who
    wishes to obtain a complete evaluation of the compound. Such monograph
    addenda are indicated by an asterisk in the "Contents", p. iii. If a
    large amount of data has become available since the previously
    published evaluation, or if the compound was first considered by the
    Joint Meeting in 1973, the pertinent monograph is reproduced in its
    entirety.

         As much relevant information as possible has been included in the
    monographs. This has been obtained from the published literature
    wherever possible, but other sources of information have also been
    used. Early and complete publication of the results of research in
    this field is very important, particularly of that part which could
    form the basis for estimation of acceptable daily intakes and
    appropriate tolerances.

         Publication allows the research to be scrutinized and criticized
    by scientists from disciplines not necessarily represented at the
    meeting. Data contained in unpublished reports, because they may
    include more detail than published work, are often acceptable.
    However, such reports must be complete and nonconfidential and
    indicate authorship.

              

    1 Pesticide residues in food. Report of the 1973 Joint Meeting of the
    FAO Working Party of Experts on Pesticide Residues and the WHO Expert
    Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
    545; FAO Agricultural Studies, No. 92.
         Two annexes have been included at the end of this series of
    monographs. Annex I is a reproduction of Annex I in the Report of the
    1973 Joint Meeting,1 and gives the recommendations concerning
    acceptable daily intakes and residue limits made at the 1973 Meeting.
    Annex II gives bibliographic references of all previous Reports and
    monographs and other publications of a general nature.

    NOTE TO THE READER

         Any comments on evaluation for acceptable daily intakes should be
    addressed to:

         Food Additives Unit
         World Health Organization
         Geneva, Switzerland,

         Any comments on residues in food and their evaluation should be
    addressed to:

         Plant Protection Service
         Plant Production and Protection Division
         Food and Agriculture Organization
         Rome, Italy

              

    1 Pesticide residues in food. Report of the 1973 Joint Meeting of the
    FAO Working Party of Experts on Pesticide Residues and the WHO Expert
    Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
    545; FAO Agricultural Studies, No. 92.























    See Also:
       Toxicological Abbreviations