IPCS INCHEM Home

    ANNEX 1

    ACCEPTABLE DAILY INTAKES, RESIDUE LIMITS AND GUIDELINE LEVELS 
    PROPOSED AT THE 1978 MEETING

         These figures are additional to, or amend, those recorded in 
    Annex 1 of the reports of earlier meetings, which are summarized in 
    document FAO/WHO 1978c.

         This Table includes maximum acceptable daily intakes (ADIs), 
    maximum residue limits (MRLs), extraneous residue limits (ERLs) and 
    guideline levels (GLs). These terms are defined in Annex 3 or the 
    Report of the 1975 Meeting (FAO/WHO, 1976a). Some ADIs or MRLs are 
    temporary: in these cases the year in which further data are required 
    is specified in parenthesis. ERLs are identified by the symbol (E) 
    after the limit. Part I lists ADIs, MRLs and ERLs. Part II lists GLs.

         New, as distinct from amended, recommendations are identified by 
    the symbol (* before the commodity or before the ADI. Residue 
    levels at or about the limit of determination are followed by 
    the symbol *. Certain corrections to previous publications are 
    included.


        PART I - ACCEPTABLE DAILY INTAKES (ADIs) AND MAXIMUM RESIDUE LIMITS (MRLs)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

    BHC (mixture of isomers)                                                                            See HCH, technical

    sec-Butylamine                  0.1                                                                 Temporary ADI extended at
    1976b, 1978b                    (1981)                                                              lower level

    Captan                          0.1          (* Potatoes              0.1
    1965b, 1970b, 1974b,
    1975b, 1978b

    Cartap                          0.1          Tea (green, dry)         20                            ADI and MRL are both
    1977b                                                                                               amended

    Chlordimeform                   0.0001       Cottonseed               2                             Limits replace all previous
    1972b, 1976b,                   (1979)       Cottonseed oil (crude)   2                             recommendations. They are
    1978b,                                       Cottonseed oil (edible)  )         No residues are     for the sum of chlordimeform
                                                 Meat of cattle           )         to occur at the     and its metabolites

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

                                                 (* Meat of pigs          )         current limit of    determined as
                                                 Meat of poultry          )         detection (0.05     4-chloro-o-toluidine and
                                                 Meat of sheep            )         mg/kg).             expressed as chlordimeform.
                                                 Milk                     )
                                                 Milk products            )

    Chlorothalonil                  0.03         (* Cereals (raw)         0.2 (1979)
    1975b, 1978b                    (1979)

    Coumaphos                       0.0005       Milk                     0.02(1980)                    Temporary ADI extended at
    1969b, 1973b,                   (1980)                                                              same level. Temporary
    1976b                                                                                               MRL for milk has been
                                                                                                        calculated from previous
                                                                                                        recommendation of 0.5
                                                                                                        mg/kg on fat basis

    Cyanofenphos                    0.005                                                               Temporary ADI extended
    1976b                           (1980)                                                              at same level

    Cyhexatin                       0.008        (* Peaches               2                             Recommended limits are
    1971b, 1974b,                   (1980)       (* Plums                 2                             now for cyhexatin and its
    1975b, 1976b,                                (* Strawberries          2                             organotin metabolites and
    1978b                                        (* Beans                 0.5 (1980)                    degradation products, determined
                                                 Meat                     0.2                           as total organic
                                                 Milk                     0.05                          tin and expressed as
                                                 Milk products (whole)    0.05                          cyhexatin. Limits for
                                                                                                        meat, milk and milk products were
                                                                                                        previously ERLs. ERLs for milk and
                                                                                                        milk products were on a
                                                                                                        fat basis at the same
                                                                                                        level.

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

    DDT                             0.005        Carcass meat             5(E) on a fat basis           Recommended MRLs and ERLs
    1965b, 1967b,                   (conditional)Fruit                    2                             replace all previously
    1968b, 1969b,                                Vegetables               2                             recommended limits. See
    1970b, 1973a,                                Milk products            1 (E) on a fat basis          Section 3.5 of Report.
    1978b                                        Eggs                     0.5 (E)
                                                 Cereals(raw)             0.2 (E)
                                                 Milk                     0.05(E)

    Dialifos                                                                                            Was not considered in
                                                                                                        1978. This entry is to
                                                                                                        correct the erroneous
                                                                                                        entry of "0.02" for MRL
                                                                                                        of "Fat of meat of cattle
                                                                                                        and sheep, milk (fat
                                                                                                        basis)" in FAO/WHO 1978c.
                                                                                                        The figure should be 0.2
                                                                                                        mg/kg.

    Dimethoate                      0.02         Hops (dried)             3                             See Section 3.4 of Report
    1965b, 1968b,                                Apples                   2                             Limits now refer
    1971b, 1974b,                                Apricots                 2                             to the sum of dimethoate
    1978b                                        Blackcurrants            2                             and omethoate (resulting
                                                 cherries                 2                             from the use of formo-
                                                 Citrus fruit             2                             thion, dimethoate or
                                                 Grapes                   2                             omethoate). MRLs apply
                                                 Olives                   2                             also to residues of
                                                 Peaches                  2 (1979)                      omethoate which has a
                                                 Pears                    2                             temporary ADI, and are
                                                 Plums                    2                             therefore classed as
                                                 Vegetables (not                                        temporary MRLs. The 
                                                 otherwise listed)        2                             previous MRL for "tree fruit
                                                 Peppers                  1                             (incld. citrus") is replaced

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

                                                 Strawberries             1                             by MRLs for the
                                                 Tomatoes                 1                             individual crops.
                                                 Potatoes                 0.05
                                                 Sugar beet, leaves       1
                                                 Sugar beet, roots        0.05

    Diquat                          0.008        (* Wheat bran            5                             MRLs of 0.2 mg/kg previously
    1971b, 1973b,                                Wheat flour (wholemeal)  2                             referred to unspecified
    1977b, 1978b                                 Wheat flour (white)      0.2                           wheat flour and to rice
                                                 Rice (hulled and/or      0.2                           (polished).
                                                   polished)

    Ethiofencarb                    0.1                                                                 Temporary ADI extended at
    1978                            (1980)                                                              same level. Previously
                                                                                                        recommended limits now
                                                                                                        refer to the sum of
                                                                                                        ethiofencarb, its sulphoxide and its
                                                                                                        sulphone.

    Fenamiphos                      0.0006       Carrots                  0.2                           All limits are now for
    1975b,1978b                                                                                         the sum of fenamiphos,
                                                                                                        its sulphoxide and its
                                                                                                        sulphone.

    Fenthion                        0.0005                                                              Temporary ADI extended
    1972b, 1976b,                   (1980)                                                              at same level.
    1978b

    Formothion                      0.02         Citrus fruit             0.2                           The MRLs for formothion on
    1970b, 1973b,                                                                                       blackcurrants and strawberries
    1974b                                                                                               are withdrawn.

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

                                                                                                        See Section 3.4 of Report.
                                                                                                        MRLs recommended for
                                                                                                        dimethoate also apply to
                                                                                                        residues resulting from
                                                                                                        the use of formothion.
                                                                                                        The ADI was inadvertently
                                                                                                        omitted from FAO/WHO1978c.

    Guazatine                       (*0.03       (* Citrus fruits         5(1980)
                                                 (* Cereals(raw)          0.1*
                                                 (* Pineapples            0.1*
                                                 (* Potatoes              0.1*
                                                 Sugar cane               0.1*

    HCH, technical                                                                                      See Section 3.6 of Report.
    1969b, 1974b                                                                                        Formerly listed an BHC
                                                                                                        (mixture of Isomers). The
                                                                                                        reference 1974b was
                                                                                                        inadvertently omitted from
                                                                                                        FAO/WHO 1978c under this
                                                                                                        heading.

    Hexachlorobenzene               No ADI                                                              Previous conditional ADI
    1970b, 1974b,                                                                                       withdrawn. See Section
    1975b                                                                                               4.33 of Report.

    Leptophos                       No ADI                                                              Previous temporary ADI and
    1975b, 1976b                                                                                        temporary MRLs withdrawn
                                                                                                        as leptophos is no longer
                                                                                                        being manufactured. Previous temporary
                                                                                                        MRLs listed in FAO/WHO 1978c.

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

    Lindane                         0.01         (* Cocoa butter          1                             MRL for milk products replaces
    1965b, 1967b,                                Cocoa mass               1                             ERL at same level.
    1968b, 1969b,                                Milk products            0.2 on a fat basis            MRL for milk replaces ERL
    1970b, 1974b,                                Milk                     0.01                          at equivalent level on
    1975b, 1976b,                                                                                       fat basis. Limits apply
    1978b                                                                                               only to residues arising
                                                                                                        from use of lindane, not
                                                                                                        those from HCH technical.

    Omethoate                       0.0005                                                              Temporary ADI extended at
    1972b, 1976b                    (1979)                                                              same level. Temporary MRLs
                                                                                                        for dimethoate apply also
                                                                                                        to omethoate. See Section
                                                                                                        3.4 of Report.

    Paraquat                        0.002        (* Sunflower meal
    1971b, 1973b,                                (animal feed
    1977b                                        component)               2
                                                 (*Sunflower oil
                                                 (crude & refined)        0.05*

    Parathion-methyl                0.001                                                               Temporary ADI extended at
    1965b, 1969b,                   (1980)                                                              same level. Temporary MRLs
    1973b, 1976b,                                                                                       now refer to the sum of
    1978b                                                                                               parathion-methyl and its
                                                                                                        oxygen analogue.

    Phosmet                         (*0.005      (* Blueberries           10                            As a temporary ADI has been
    1977b, 1978b                    (1979)       (* Kiwifruit             10                            allocated, previous GLs are
                                                 (* Sweet potatoes        10 product washed before      replaced by the temporary MR
                                                                          analysis                      MRLs shown. Limit for whole
                                                 (* Citrus fruit          5                             milk is equivalent to former

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

                                                 (* Cranberries           5                             GL on fat basis. Limits now
                                                 Forage crops(dry)        5                             refer to the sum of phosmet
                                                 (* Grapes                5                             and its oxygen analogue.
                                                 Apples                   1
                                                 (* Apricots              1         (1979)
                                                 (* Nectarines            1
                                                 Peaches                  1
                                                 (* Pears                 1
                                                 Fat of meat of cattle    1
                                                 (* Maize                 0.2 kernels and cobs, with
                                                                          husks removed
                                                 Milk products            0.2 on a fat basis
                                                 (* Peas(fresh or dried)  0.1
                                                 (* Tree nuts             0.1 on shell free basis
                                                 Potatoes                 0.05
                                                 Milk                     0.01

    Pirimicarb                      0.01         (* Alfalfa, green        50        dry weight basis    Temporary ADI extended
    1977b                           (1980)       (* Alfalfa, hay          20        dry weight basis    at higher level.
                                                 (* Barley                0.05*                         Limits are now for
                                                 (* Eggs                  0.05*     shell free (1980)   sum of pirimicarb, its
                                                 (* Meat                  0.05*                         N-formyl-(methylamino)
                                                 (* Milk                  0.05*                         analogue desmethyl
                                                 (* Oats                  0.05*                         formamido-pirimicarb)
                                                                                                        and desmethyl-pirimicarb

    Propargite                      0.08         (* Tea(dry,
                                                     manufactured)        5
    1978b                                        Apples                   2
                                                 Figs                     2         (1981)
                                                 Pears                    2

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

                                                 (* Tomatoes              2
                                                 (* Cucumbers             0.5

    Tecnazene                       (*0.01       (* Lettuce               2
    1975b                           (1981)       (* Potatoes              1 washed before analysis
                                                 (* Chicory(witloof)      0.2       (1981)
                                                 (* Tomatoes              0.1
                                                 (* Vegetables(except
                                                         chicory)         0.1

    Thiometon                                                                                           Not considered in 1978.
                                                                                                        This entry is to draw
                                                                                                        attention to (1)
                                                                                                        omission of reference 1977b
                                                                                                        and (2) omission of
                                                                                                        maize (leaves, stalks,
                                                                                                        cobs) at 0.1* mg/kg
                                                                                                        and (3) erroneous
                                                                                                        listing of fodder beets
                                                                                                        at 0.1* mg/kg instead of
                                                                                                        0.05* mg/kg in 1977a
                                                                                                        and 1978c

    Thiophanate-methyl              0.08                                                                See Section 3.3 of Report.
    1974b, 1976b,                                                                                       Previously recommended MRLs
    1978b                                                                                               now apply to thiophanate-methyl alone.
                                                                                                        expressed as carbendazim. They
                                                                                                        previously applied to the sum
                                                                                                        of thiophanate-methyl and
                                                                                                        carbendazim, expressed as
                                                                                                        carbendazim.

    PART I - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)   (mg/kg)                  (mg/kg)
                                                                                                                                         

    Trichlorfon                     0.01         Apples                   2                             ADI replaces temporary ADI
    i972b, 1976b                                 Strawberries             1                             at same level.
                                                 Cabbage                  0.5
                                                 (* Grapes                0.5
                                                 (* Meat of sheep         0.1
                                                 (* Radishes              0.1
                                                 (* Carrots               0.05
                                                 (* Eggplants             0.05
                                                 (* Parsley               0.05

    Triforine                       (*0.02       (* Peaches               5                             MRLs are for residues
                                                 (* Apples                2                             determined as chloral
                                                 (* Cherries              2                             hydrate and expressed as
                                                 (* Plums                 2                             triforine.
                                                 (* Beans                 1
                                                 (* Blackcurrants         1
                                                 (* Blueberries           1
                                                 (* Gooseberries          1
                                                 (* Red currants          1
                                                 (* Strawberries          1
                                                 (* Cucurbits             0.5
                                                 (* Tomatoes              0.5
                                                 (* Brussels sprouts      0.2
                                                 (* Cereals(raw)          0.1
                                                 (* Tamarillo             0.02
                                                                                                                                         

    PART II - GUIDELINE LEVELS (GLs) (NO ACCEPTABLE DAILY INTAKES)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)                            (mg/kg)   (mg/kg)
                                                                                                                                         

    Benomyl                         No ADI                                                              GLs previously recommended
    1974b, 1976b                                                                                        for benomyl are replaced
                                                                                                        by carbendazim. The GLs
                                                                                                        refer to carbendazim
                                                                                                        residues, whether occurring
                                                                                                        as a metabolic product of
                                                                                                        benomyl or of thiophanate-methyl
                                                                                                        or from the direct
                                                                                                        use of carbendazim. See
                                                                                                        Section 3.3 of the Report.

    Bioresmethrin                   No ADI       Raw cereals                        5                   This compound was not
    1976b                                        Milled products                                        considered in 1978. This
                                                 from raw cereals                   5                   entry is included here
                                                 Cooked cereal                      5                   because the Gls recorded in
                                                 products including                                     1975, were inadvertently
                                                 bread                              0.05*               omitted from FAO/WHO
                                                                                                        (1978c).

    Carbendazim                     No ADI       (* Bean vines                      30                  These Gls replace separate
    1974b, 1977b,                                Cherries                           10                  Gls for benomyl and carbendazim.
    1978b                                        Citrus fruit                       10                  See Section 3.3 of
                                                 Peaches                            10                  Report. No ADI because
                                                 Apples                             5                   toxicological data have
                                                 (* Apricots                        5                   not been made available.
                                                 (* Blackberries                    5
                                                 (* Blackcurrants                   5
                                                 Boysenberries                      5
                                                 Carrots                            5
                                                 (*Dewberries                       5

    PART II - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)                            (mg/kg)   (mg/kg)
                                                                                                                                         

                                                 Gooseberries                       5
                                                 Grapes                             5
                                                 Lettuce                            5
                                                 (* Loganberries                    5
                                                 Pears                              5
                                                 (* Raspberries                     5
                                                 Strawberries                       5
                                                 Sugarbeet tops                     5
                                                 Tomatoes                           5
                                                 (*Potatoes                         3 in the
                                                                                    product washed
                                                                                    before analysis
                                                 (*Barley straw                     2
                                                 Celery                             2
                                                 (* Dry beans                       2
                                                 Dwarf beans                        2
                                                 Gherkins                           2
                                                 (* Lima beans                      2
                                                 (* Mangoes                         2
                                                 (* Nectarines                      2
                                                 Plums                              2
                                                 (* Prunes                          2
                                                 Peanut hay                         2
                                                 (* Rice straw                      2
                                                 (* Snap beans                      2
                                                 Wheat straw                        2
                                                 (* Almond hulls                    1
                                                 Bananas                            1 in the
                                                                                    whole product
                                                 Mushrooms                          1
                                                 (* Avocados                        0.5

    PART II - (Cont'd.)

                                                                                                                                         

    Pesticide and previous                                                MRL or    Guideline
    evaluations (Refs. are to       ADI          Commodity                ERL       level               Remarks
    list of FAO/WHO publications)   (mg/kg bw)                            (mg/kg)   (mg/kg)
                                                                                                                                         


                                                 Banana                             0.5 in the pulp
                                                 Barley                             0.5
                                                 (* Brussels sprouts                0.5
                                                 Cucumbers                          0.5
                                                 Melons                             0.5
                                                 Rice                               0.5
                                                 Rye                                0.5
                                                 (* Squash                          0.5
                                                 Wheat                              0.5
                                                 Peanut hulls                       0.2
                                                 (* Almonds                         0.1*
                                                 Coffee beans(raw)                  0.1*
                                                 (* Eggs                            0.1* shell-free
                                                                                    basis
                                                 (* Macadamia nuts                  0.1*
                                                 (* Meat of cattle                  0.1*
                                                 (* Meat of poultry                 0.1*
                                                 (* Meat of sheep                   0.1*
                                                 (* Milk                            0.1*
                                                 Peanuts                            0.1*
                                                 (* Pecans                          0.1*
                                                 Sugar beet                         0.1*

    Ethephon                        No ADI       (* Grapes                          10                  No ADI allocated because toxicological
    1978b                                        (* Onions (bulb)                   0.5                 data were insufficient
                                                 (* Peaches                         0.5                 for evaluation.
                                                                                                                                         
        




























    See Also:
       Toxicological Abbreviations