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    PESTICIDE RESIDUES IN FOOD - 1983


    Sponsored jointly by FAO and WHO






    EVALUATIONS 1983





    Data and recommendations of the joint meeting
    of the FAO Panel of Experts on Pesticide Residues
    in Food and the Environment and the
    WHO Expert Group on Pesticide Residues
    Geneva, 5 - 14 December 1983

    Food and Agriculture Organization of the United Nations
    Rome 1985

    The designations employed and the presentation of material in this
    publication do not imply the expression of any opinion whatsoever on
    the part of the Food and Agriculture Organization of the United
    Nations concerning the legal status of any country, city or area or of
    its authorities, or concerning the delimitation of its frontiers or
    boundaries.

    M-84
    ISBN 92-5 102222-4

    All rights reserved.  No part of this publication may be reproduced,
    stored in a retrieval system, or transmitted in any form or by any
    means, electronic, mechanical, photocopying or otherwise, without the
    prior permission of the copyright owner.  Applications for such
    permission, with a statement of the purpose and extent of the
    reproduction, should be addressed to the Director, Publications
    Division, Food and Agriculture Organization of the United Nations, Via
    delle Terme di Caracalla, 00100 Rome, Italy.

    (c) FAO 1985

    CONTENTS

    List of Those Attending the Meeting

    Introduction

    The Monographs

         Amitraz*
              Residues

         Azinphos-ethyl*
              Residues

         Azocyclotin
              Residues

         Benomyl*
              Toxicology
              Residues

         Bitertanol
              Toxicology

         Bromide Ion
              Residues

         Butocarboxim
              Residues

         Carbendazim*
              Toxicology
              Residues

         Carbophenothion*
              Residues

         Chinomethionat*
              Residues

         Chlorothalonil*
              Toxicology
              Residues

         Chlorpyrifos*
              Residues

         Coumaphos*
              Residues

         Cyhexatin*
              Residue

         Cypermethrin*
              Residues

         Daminozide*
              Toxicology

         Dichlofluanid*
              Toxicology
              Residues

         Diflubenzuron*
              Residues

         Dimethoate*
              Residues

         Dithiocarbamates*
              Residues

         Ethephon*
              Residues

         Ethiofencarb*
              Residues

         Ethion*
              Residues

         Ethoprophos
              Toxicology

         Fenchlorphos*
              Residues

         Fenitrothion*
              Residues

         Fensulfothion*
              Residues

         Fenthion*
              Residues

         Mecarbam*
              Toxicology
              Residues

         Methiocarb*
              Toxicology
              Residues

         Nitrofen
              Toxicology
              Residues

         Oxamyl*
              Residues

         Permethrin*
              Residues

         Phoxim
              Residues

         Pirimiphos-methyl*
              Residues

         Prochloraz
              Toxicology
              Residues

         Propoxur*
              Residues

         Triadimefon*
              Toxicology
              Residues

         Triazophos*
              Residues

    Annex I - Acceptable daily intakes, maximum residue limits and
    guideline levels proposed at the 1983 Meeting

    Annex II - Previous FAO and WHO Documentation

              

    *  Addendum
    

    1983 JOINT MEETING OF THE FAO PANEL OF EXPERTS ON PESTICIDE RESIDUES

    IN FOOD AND THE ENVIRONMENT AND THE WHO EXPERT GROUP ON PESTICIDE
    RESIDUES

    Geneva, 5-14 December 1983

    FAO Panel of Experts on Pesticide Residues in Food and the
    Environment

    A. Ambrus, Plant Protection and Agrochemistry Centre, Budapest,
         Hungary

    J.A.R. Bates, Pesticide Registration Department, Ministry of
         Agriculture, Fisheries and Food, Hatching Green, Harpenden,
         Herts, UK(Rapporteur)

    K.R. Hill, Chemistry Laboratory, US Department of Agriculture,
         Agricultural Environment Quality Institute, Beltsville, Md, USA
         (Chairman)

    N.F. Ives, Office of Pesticide Programs, Environmental Protection
         Agency, Washington DC, USA

    J.T. Snelson, Department of Primary Industry, Canberra, Australia
         Vice-Chairman)

    Voldum-Clausen, Division of Pesticides and Contaminants, National Food
         Institute, Soborg, Denmark

    Observer invited by FAO

    A.J. Pieters, Directorate of Public Health, Foodstuffs Division,
         Leidschendam, The Netherlands (Chairman of the Codex Committee on
         Pesticide Residues)

    WHO Expert Group on Pesticide Residues

    V. Benes, Department of Toxicology, Institute of Hygiene and
         Epidemiology, Prague, Czechoslovakia

    D. Clegg, Pesticide Section, Toxicological Evaluation Division, Food
         Directorate, Health Protection Branch, Ottawa, Canada (Chairman)

    S. Jetanasen*, Epidemiology Division, Office of the Under-Secretary,
         Ministry of Public Health, Bangkok, Thailand

    M. Lotti, Istituto di Medicina del Lavoro, Padua, Italy (Rapporteur)

    D. de Paola, Department of Pathology, School of Medicine, Federal
         University, Rio de Janeiro, Brazil

    O.E. Paynter, Hazard Evaluation Division, US Environmental Protection
         Agency, Washington DC, USA

    FAO/WHO Secretariat

    A. L. Black, Commonwealth Department of Health, Woden, Australia (WHO
         Temporary Adviser)

    J.R. Cabral, Unit of Mechanisms of Carcinogenesis, International
         Agency for Research on Cancer, Lyon, France

    A. di Muccio, Toxicological Laboratory - Pesticide Section, Instituto
         Superiore di Sanita, Rome, Italy (WHO Temporary Adviser)

    R. B. Jaeger, Toxicology Branch, Hazard Evaluation Division, US
         Environmental Protection Agency, Washington DC, USA (WHO
         Temporary Adviser)

    F-W. Kopisch-Obuch, Plant Protection Service, FAO, Rome, Italy
         (Secretary of FAO Panel of Experts on Pesticide Residues in Food
         and the Environment)

    L. G Ladomery, Joint FAO/WHO Food Standards Programme, FAO, Rome,
         Italy

    A.F. Machin, Ministry of Agriculture, Fisheries and Food, Central
         Veterinary Laboratory, Weybridge, Surrey, UK (FAO Consultant)

    T. Pekkanen, Department of Food Hygiene, College of Veterinary
         Medicine, Helsinki, Finland (WHO Temporary Adviser)

    M. Repetto*, Regional Toxicology Institute, Seville, Spain (WHO
         Temporary Adviser)

    M. Tobe, Toxicological Division, National Institute of Hygienic
         Sciences, Tokyo, Japan (WHO Temporary Adviser)

    G. Vettorazzi, International Programme on Chemical Safety, Division of
         Environmental Health, WHO, Geneva, Switzerland (Secretary of the
         WHO Export Group on Pesticide Residues)

    E. Weisenberg, Institute for the Standardization and Control of
         Pharmaceuticals, Ministry of Health, Jerusalem, Israel (WHO
         Temporary Adviser)

    D.L. Wu-Lau*, Pesticides Section, Toxicology Evaluation Division, Food
         Directorate, Health Protection Branch, Ottawa, Canada (WHO
         Temporary Adviser

    Additional WHO Temporary Advisers**

    E.R. Budd, Office of Pesticide Programs, US Environmental Protection
         Agency, Washington DC, USA

    N. Ito, First Department of Pathology, Nagoya City University, Medical
         School, Nagoya, Japan

    P. Shubik, Green College at the Radcliffe Observatory, Oxford OX2
         6HG,UK

              

    *    Invited but unable to attend

    **   Present only at the discussion of o-phenylphenol and its sodium
         salt

    INTRODUCTION

         The report of the Joint Meeting of the FAO Panel of Experts on
    Pesticide Residues in Food and the Environment and the WHO Expert
    Group on Pesticide Residues, held in Rome from 24 September to
    3 October 1984 contains a summary of the evaluations of residues in
    foods of the various pesticides considered at the session as well as
    information on the general principles followed by the Meeting. The
    present document contains summaries of the data considered, together
    with the recommendations made.

         The information included in the monographs has been obtained from
    the published literature wherever possible, but other sources have
    also been included. Early and complete publication of the results of
    research in this field are very important, particularly those data
    which can form the basis for the estimation of acceptable daily
    intakes and appropriate residue levels. Publication allows the
    research to be assessed by scientists from disciplines not necessarily
    represented at the meeting. Data contained in unpublished reports are
    less satisfactory and, when considered, must be complete and
    nonconfidential and indicate authorship.

         Some of the compounds considered At this Meeting have been
    previously evaluated and reported on in earlier publications. Only new
    information is summarized in the relevant monographs and reference is
    made to the previously published evaluation(s), which should also be
    consulted. Such monograph addenda are indicated by an asterisk in the
    "Contents" sheet.

         Annex 1 to this volume of monographs summarizes the
    recommendations on acceptable daily intakes, maximum residue limits
    and guideline levels made at the 1984 Meeting. It has already appeared
    as an annex to the report of the Meeting.

    NOTE

         Any comments on evaluation for acceptable daily intake should be
    addressed to:

    Food Safety Unit
    World Health Organization
    Geneva, Switzerland

         Any comments on residues in food and their evaluation should be
    addressed to:

    Pesticide Residues Specialist
    Plant Protection Service
    Plant Production and Protection Division
    Food and Agriculture Organization
    Rome, Italy






















    See Also:
       Toxicological Abbreviations