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    PESTICIDE RESIDUES IN FOOD - 1984


    Sponsored jointly by FAO and WHO






    EVALUATIONS 1984




    The monographs



    Data and recommendations of the joint meeting
    of the FAO Panel of Experts on Pesticide Residues
    in Food and the Environment and the
    WHO Expert Group on Pesticide Residues
    Rome, 24 September - 3 October 1984

    Food and Agriculture Organization of the United Nations
    Rome 1985

    DEMETON-S-METHYL AND RELATED COMPOUNDS
    (DEMETON-S-METHYL,OXYDEMETON-METHYL SULPHOXIDE),
    AND DEMETON-S-METHYL SULPHONE)

    Explanation

         One member of this group of compounds, oxydemeton-methyl
    (demeton-S-methyl sulphoxide), was reviewed at the 1965, 1967 and 1968
    meetings1/. On the basis of the studies available at that time,
    primarily short-term studies, an acceptable daily intake for man was
    estimated at the 1965 meeting to be 0-0.0025 mg/kg/day. When further
    considered at the 1967 meeting new data, primarily a three-generation
    reproduction study, were reviewed and the ADI for man re-affirmed to
    be 0-0.0025 mg/kg/day. The 1968 meeting re-evaluated this compound and
    concluded that the available information revealed that the toxicology
    was not related to a single defined compound nor was there precise
    knowledge of the materials actually used in agricultural practice.
    Furthermore, no long-term data on any of the substances belonging to
    this group were available for evaluation.  That meeting, therefore,
    recommended that the ADI as established at previous meetings should no
    longer be considered valid. The further work required to allow full
    assessment to be made included:  specifications of the compound or
    compounds in actual agricultural use; studies to compare the metabolic
    fate in animals, plants and man; investigation of the cholinesterase
    inhibition in man and adequate long-term studies in two species. Some
    of these requirements were met and considered at the 1973 JMPR when an
    ADI of 0-0.005 mg/kg was estimated for the total of all three
    compounds.

         The 1981 JMPR identified this group of compounds (referred to,
    however, as "demeton and related compounds") as one for which the ADI
    was partially based on IBT data and the 1982 JMPR, in the absence of
    validated long-term toxicity studies, agreed to withdraw the ADI. As a
    consequence, the MRLs were withdrawn and replaced by GLs. Since then,
    data on current use patterns and new data on residues in various crops
    and commodities have become available and are reviewed together with
    new information on the stability of these compounds in soil, in this
    monograph addendum.

    RESIDUES IN FOOD AND THEIR EVALUATION

    USE PATTERN

         Demeton-S-methyl, oxydemeton-methyl and demeton-S-methyl sulphone
    are systemic compounds which have a fast action and long-lasting
    activity against sucking insect pests (aphids, thrips, whiteflies,
    hoppers, etc.) and spider mites. They also control pests with
    concealed habits. By giving good control of virus vectors, they very
    largely prevent fresh infections and virus disease spread. Each of the
    three compounds displays good crop compatibility.

              
    1/  See Annex 2 for FAO and WHO documentation.

         Tables 1 to 4 summarize the currently recommended use patterns of
    demeton-S-methyl, oxydemeton-methyl and demeton-S-methyl sulphone.

    RESIDUES RESULTING FROM SUPERVISED TRIALS

    Tables 5, 6 and 7 summarize the new data on residues from extensive
    trials from 1974 to 1982 with all three compounds on a number of
    crops. In all analyses the residues were oxidised to the sulphone and
    calculated as demeton-S-methyl, the limit of determination being
    0.01 mg/kg.

    FATE OF RESIDUES

    In animals

         An earlier study had shown no effects from feeding rations
    containing 5 ppm oxydemeton-methyl to poultry for 28 days. A further
    study (Thornton, 1975) was conducted to determine the effects, if any,
    of feeding higher levels of oxydemeton-methyl to chickens. Poultry
    rations containing 15 and 30 ppm oxydemeton-methyl, were fed
    continuously for 28 days. At the end of that period, the birds were
    sacrificed and tissues and eggs were analyzed for residues. Twelve
    laying hens (breed, Babcock 300), approximately 25 weeks old, were
    caged individually and fed and watered ad lib. for a two-week
    period which was sufficient to establish good egg production and feed
    consumption.

         Residue analysis of muscle, giblet, skin and fat tissues showed
    no detectable residues of oxydemeton-methyl in the chickens fed 15 ppm
    fortified feed. At the 30 ppm level, no detectable residues were found
    in any tissue except giblets which all contained 0.01 mg/kg. However,
    this value is at the extreme limit of sensitivity for tissue analyses
    and cannot be considered significant. Twenty-eight day egg residues
    from chickens fed 15 ppm showed measurable residues of 0.002 mg/kg
    which is near the limit of determination of the method for eggs. At
    the 30 ppm feeding level, residues were measured up to 0.005 mg/kg.

    In soil

         A 5 mg/l aqueous solution of oxydemeton-methyl (methoxy-14C)
    irradiated with light from the visible and ultraviolet portion of the
    spectrum did not appear to be rapidly degraded. The half-life of the
    parent compound under these conditions was 16 days. By comparison, the
    half-life of oxydemeton-methyl in a solution containing 2% acetone as
    a triplet sensitizer was 4 days. Degradation products in the aqueous
    solution included demeton-S-methyl sulphone, dimethyl phosphate and
    dimethyl phosphorothioate.

         Oxydemeton-methyl irradiated on the surface of silt loam soil did
    not appear to be significantly altered by light in comparison to
    degradation by other factors (Nichols and Thornton, 1978).


        Table 1.  Use pattern of demeton-S-methyl

                                                                                                                  

                                                      Europe    Asia      Africa    Australia      South and
                                                                                    and New        Central
                                                                                    Zealand        America
                                                                                                                  

    Sugar and fodder beet         125-200 g/ha        X                                            X

    Potatoes                      175-400 g/ha        X                             X              X

    Pome fruit                    0.025 %             X         X                                  X
    (apples, pears)


    Cereals                       75-125 g/ha         X                   X                        X


    Ornamentals,                                                          X                        X
    tree nurseries
                                                                                                                  

    Table 2.  Use pattern of oxydemeton-methyl

                                                                                                                  

                                                      Europe    Asia      Africa    Australia      South and
                                                                                    and New        Central
                                                                                    Zealand        America
                                                                                                                  

    Sugar and fodder beet         125-200 g/ha        X         X

    Potatoes                      175-400 g/ha        X         X                                  X

    Pome fruit                    0.025 %             X         X         X                        X
    (apples, pears)

    Stone and small fruit         0.025 %             X         X         X
    Apricots
    Strawberries
    Currants
    Cherries
    Peaches
    Plums

    Grapes                        0.025 %             X         X                                  X

    Cereals                       75-125 g/ha         X                   X

    Maize, Sorghum                175-200 g/ha                  X                                  X

    Citrus fruit                  0.025 %             X         X         X                        X

    Alfalfa                       250 g/ha                                                         X

                                                                                                                  

    Table 2.  (continued)

                                                                                                                  

                                                      Europe    Asia      Africa    Australia      South and
                                                                                    and New        Central
                                                                                    Zealand        America
                                                                                                                  

    Vegetables                    125-300 g/ha        X         X         X                        X
    Eggplants
    Beans
    Broccoli
    Peas
    Cucumbers
    Brassicas (Kale,
    Brussels sprouts,
    Cauliflower)
    Kohlrabi
    Pumpkins, Squash
    Melons
    Carrots
    Head Lettuce
    Tomatoes
    Onions

    Ornamentals,                                      X         X
    tree nurseries                                                        X                        X
                                                                                                                  

    Table 3.  Use pattern of demeton-S-methyl sulphone (in "Gusathion MS"*)

                                                                                                                  

                                                      Europe    Asia      Africa    Australia      South and
                                                                                    and New        Central
                                                                                    Zealand        America
                                                                                                                  

    Pome fruit                    0.015 %             X                   X
    Apples, pears

    Stone and small fruit         0.015 %             X

    Strawberries, currants
    cherries, plums

    Grapes                        0.015 %             X
                                                                                                                  

    * "Gusathion MS" also contains azinphos-methyl.
    

    Table 4.  Use pattern of oxydemeton-methyl in the USA

                                                                        

    Crops                                        Dose, a.i.
                                                                        

    Cotton                                       437 - 585 g/ha
    Corn                                         437 - 585 g/ha
    Sorghum                                      292 - 585 g/ha
    Sugar beets                                  437 - 877 g/ha
    Alfalfa                                      437 - 585 g/ha
    Blackberries, Raspberries                    0,032 - 0,047 %
    Grapes, Lemons, Oranges                      0,032 - 0,047 %
    Pears                                        0,032 %
    Plums, Prunes                                0,032 %
    Strawberries                                 437 - 877 g/ha
    Beans                                        585 g/ha
    Broccoli, Brussels sprouts, Cauliflower      437 - 585 g/ha
    Cabbage                                      437 - 877 g/ha
    Cucumbers                                    437 - 585 g/ha
    Eggplant                                     585 g/ha
    Head lettuce                                 437 - 585 g/ha
    Spanish onions (bulb)                        877 g/ha
    Peas                                         437 g/ha
    Peppers                                      585 g/ha
    Potatoes                                     437 - 585 g/ha
    Pumpkin, Squash (Winter and Summer)          437 - 585 g/ha
    Turnips                                      437 - 585 g/ha
    Muskmelon (cantaloupe), other melons         437 - 587 g/ha
    Watermelons                                  437 - 585 g/ha
    Walnuts                                      0,047 %
                                                                        


        Table 5.  Residues of demeton-S-methyl in sugar beet, potatoes and apples

                                                                                                                            

    Crops               Dose a.i.      No. of         Country        Interval,            Residue mg/kg           Report
                                       applications                  days           range          average        No.
                                                                                                                            

    Sugar beets         200 g/ha       3-4            FRG                                                         BAYER
    Roots                                                             0              0.06           0.06 (1)      4903 -
                                                                     13             <0.01          <0.01 (1)      4904/75
                                                                     21              n.d.           n.d. (1)      4900 -
                                                                     28/30           n.d. -<0.01   <0.01 (4)      4902/77
                                                                     35              n.d.           n.d. (3)
                                                                     42/43           n.d.           n.d. (3)
                                                                     59-85           n.d.           n. d. (6)

    Leaves                                                            0              2.57           2.57 (1)
                                                                     13              0.24           0.24 (1)
                                                                     21             <0.01          <0.01 (1)
                                                                     28/30           n.d. - 0.02   <0.01 (4)
                                                                     35              n.d.           n.d. (3)
                                                                     42/43           n.d.           n.d. (3)
                                                                     59-85           n.d.           n.d. (6)

    Potatoes            200 -          3              FRG             0              0.06 - 0.11    0.08 (3)      BAYER
                        300 g/ha                                     14             <0.01 - 0.01    0.01 (3)      4900 -
                                                                     21/22           0.01 - 0.05    0.02 (3)      4902/74
                                                                     28/29          <0.01          <0.01 (3)

    Apples              0.025          4              FRG             0              0.81 - 0.88    0.85 (3)      4900 -
                                                                      7              0.48 - 0.64    0.54 (3)      4902/75
                                                                     14              0.47 - 0.59    0.52 (3)
                                                                     21              0.42 - 0.54    0.47 (3)
                                                                     28              0.25 - 0.41    0.33 (3)
                                                                                                                            

    Values in parentheses indicate number of individual results.

    Table 6.  Residues from the use of oxydemeton-methyl in trials on various crops

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Sugar beets         200 g/ha       4              FRG
    Roots                                                             0              0.02 - 0.05         0.03 (3)      BAYER
                                                                     28              0.02 - 0.05         0.03 (3)      4842 -
                                                                     35              0.02 - 0.05         0.03 (3)      4844/79
                                                                     42              0.02 - 0.05         0.03 (3)
                                                                     49              0.02 - 0.05         0.03 (3)
                                                                     77-88           0.02 - 0.05         0.04 (3)

    Leaves                                                            0              1.11 - 2.02         1.58 (3)
                                                                     28              0.02 - 0.03         0.03 (3)
                                                                     35              0.02 - 0.03         0.03 (3)
                                                                     42              0.02 - 0.34         0.13 (3)
                                                                     49              0.02 - 0.36         0.14 (3)
                                                                     77-88           0.02 - 0.03         0.03 (3)

    Potatoes            200 -          3              FRG             0             <0.02 - 0.04*        0.03 (3)      BAYER
                        300 g/ha                                     14              0.04 - 0.10*        0.07 (3)      4800 -
                                                                     21/22           0.02 - 0.08*        0.04 (3)      4802/74
                                                                     28              0.04*               0.04 (1)

    Apples              0,025 %        4              FRG             0             <0.04 - 1.9          0.74 (6)      BAYER
                                                                     10/14          <0.04 - 1.5          0.54 (6)      4823 -
                                                                     21             <0.04 - 0.96         0.33 (6)      4824/75
                                                                     28             <0.04 - 0.56         0.22 (6)      4806 -
                                                                     35             <0.04 - 0.46         0.24 (6)      4807/82
                                                                                                                       4819 -
                                                                                                                       4820/82
                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Pears               0.025 %        4              FRG             0              0.04 - 1.7          0.71 (4)      BAYER
                                                                     10             <0.01 - 0.67         0.26 (4)      4809 -
                                                                     21              n.d. - 0.49         0.16 (4)      4810/82
                                                                     28              n.d. - 0.33         0.12 (4)      4821 -
                                                                     35              n.d. - 0.30         0.10 (4)      4822/82

    Strawberries        0.025 %        2              FRG             0              0.41 - 0.58         0.50 (2)      BAYER
                                                                      7              0.23                0.23 (2)      4808 -
                                                                     14              0.09 - 0.11         0.10 (2)      4809/76
                                                                     21              0.03 - 0.06         0.05 (2)
                                                                     28              0.02                0.02 (2)

    Currants, black     0.025 %        2              FRG             0              1.9 - 9.2           5.71 (6)      BAYER
                                                                      7              0.89 - 4.02         3.02 (6)      4800 -
                                                                     12/14           0.50 - 2.4          1.65 (6)      4802/76
                                                                     19/21           0.41 - 1.59         1.13 (6)      4834 -
                                                                     26/28           0.22 - 1.33         0.79 (6)      4836/79
                                                                     33/35           0.30 - 0.73         0.49 (4)
                                                                     40              0.24                0.24 (1)

    Currants, red       0.025 %        2              FRG             0              2.87 - 7.91         5.22 (6)      BAYER
                                                                      7              0.55 - 5.16         2.65 (6)      4803 -
                                                                     14              0.42 - 4.40         1.87 (6)      4805/76
                                                                     21              0.37 - 2.61         1.50 (6)      4837 -
                                                                     28              0.41 - 1.17         0.91 (6)      4839/79
                                                                     35              0.28 - 1.28         0.69 (3)

                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Cherries            0.025 %        4              FRG             0              1.08 - 2.16         1.76 (3)      BAYER
                                                                      7              1.01 - 1.57         1.26 (3)      4825-
                                                                     14             <0.04- 1.39          0.52 (3)      4827/79
                                                                     21              0.12 - 1.32         0.58 (3)
                                                                     28             <0.04 - 0.62         0.41 (3)

    Peaches             0.025 %        4              FRG             0             <0.04 - 6.0          2.22 (6)      BAYER
                                                                      7             <0.04 - 1.3          0.64 (6)      465-
                                                                     14             <0.04 - 1.3          0.53 (6)      467/73
                                                                     21             <0.04 - 0.56         0.23 (6)      4832/79
                                                                     28             <0.04 - 0.4          0.18 (6)      4805 -
                                                                                                                       4806/80

    Plums               0.025 %        2-4            FRG             0              0.12 - 0.76         0.37 (6)      BAYER
                                                                      7              0.1 - 0.60          0.25 (6)      462 -
                                                                     14             <0.04 - 0.41         0.21 (6)      464/73
                                                                     21              0.06 - 0.61         0.27 (6)      4828 -
                                                                     28              0.08 - 0.24         0.14 (6)      4830/79

    Grapes              0.025 %        3              FRG             0              0.55 - 1.9          1.11 (5)      BAYER
                                                                     21              0.5 - 1.4           0.88 (5)      4837-
                                                                     28              0.05 - 0.87         0.55 (5)      4839/75
                                                                     55              0.1 - 0.55          0.43 (5)      4840 -
                                                                     42              0.06 - 0.75         0.41 (5)      4841/79
                                                                     49              0.07 - 0.7          0.41 (5)
                                                                     62              0.05                0.05 (1)

    Must                                                                             0.07 - 0.65         0.36 (3)

                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Wine                                                                             0.08 - 0.4          0.26 (3)

                        0.045 -        2              USA            49              0.42 - 1.21         0.93 (3)      MOBAY
                        0.075 %                                      56/58           0.10 - 0.72         0.40 (4)      45057,
                                                                     61/63          <0.05- 2.43          0.92 (4)      43063,
                                                                     72              0.19                0.19 (1)      69786,
                                                                     91-151         <0.05               <0.05 (6)      69800,
                                                                                                                       69801,
    Juice                                                            122            <0.05               <0.05 (1)      69803

    Wet pomace                                                       122            <0.05               <0.05 (1)

    Dry pomace                                                       122            <0.05               <0.05 (1)

    Barley              125 g/ha       2              FRG                                                              BAYER
    Green forage                                                      0              2.0 - 2.9           2.5 (3)       4803
                                                                      7              0.33 - 3.2          1.88 (3)      4805/82
                                                                     14              0.11                0.11 (1)

    Ears                                                              0              1.6 - 3.8           2.47 (3)
                                                                      7              0.38 - 3.5          1.63 (3)
                                                                     14              0.12                0.12 (1)

    Straw                                                            14              0.65 - 1.1          0.88 (2)
                                                                     21             <0.01 - 0.97         0.36 (3)
                                                                     28             <0.01 - <0.02       <0.02 (3)

    Grains                                                           14              0.04 - 0.25         0.15 (2)
                                                                     21             <0.01 - 0.1          0.05 (5)
                                                                     28             <0.01 - 0.08         0.04 (3)
                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Oats                125 g/ha       2              FRG
    Green forage                                                      0              0.48 - 2.5          1.57 (3)      BAYER
                                                                      7              0.01 - 1.7          1.00 (3)      4800 -
                                                                     14              0.01 - 0.77         0.31 (3)      4802/82

    Ears                                                              0              0.25 - 3.40         1.78 (3)
                                                                      7              0.18 - 1.7          0.96 (3)
                                                                     14              0.18 - 1.1          0.67 (3)

    Straw                                                            21             <0.02 - 0.12         0.07 (3)
                                                                     28             <0.02 - 0.17         0.06 (3)

    Grains                                                           21             <0.02 - 0.08         0.03 (3)
                                                                     28             <0.02 - 0.03         0.02 (3)

    Wheat               200 g/ha       2              FRG                                                              BAYER
    Green forage                                                      0              1.63                1.63 (1)      4800-
                                                                      7              0.28                0.28 (1)      4802/79
                                                                     14              0.33                0.33 (1)

    Ears                                                              0              0.27 - 1.80         1.07 (3)
                                                                      7             <0.05 - 0.24         0.16 (3)
                                                                     14             <0.02 - 0.09         0.04 (5,)
                                                                     21             <0.02               <0.02 (1)

    Straw                                                             0             <0.05 - 1.60         0.81 (2)
                                                                      7             <0.05               <0.05 (2)
                                                                     14             <0.05               <0.05 (2)
                                                                     21             <0.05 - 0.04        <0.05 (2)
                                                                     28             <0.05 - 0.02 <0,05 (3)
                                                                     35              n.d.                n.d. (1)
                                                                     42              n.d.                n.d. (1)
                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Grains                                                           21             <0.05 - 0.07        <0.05 (2)
                                                                     28             <0.02 - 0.22         0.09 (3)
                                                                     35              n.d.                n.d. (1)
                                                                     42              n.d.                n.d. (1)

    Corn                560 g/ha       3              USA                                                              MOBAY
    Green forage                                                      0              2.18 - 16.7        10.23 (7)      67456,
                                                                      3              0.30 - 10.4         3.87 (7)      67457,
                                                                      7              0.98 - 4.87         1.90 (6)      67459,
                                                                     14              0.15 - 3.36         1.53 (4)      67491 -
                                                                     21              0.10 - 2.73         0.85 (4)      67494

    Milk stage                                                        0             <0.01 - 0.06         0.03 (7)
    kernel                                                            3             <0.01 - 0.04         0.02 (3)
                                                                      7             <0.01               <0.01 (3)
                                                                     14             <0.01               <0.01 (3)
                                                                     21             <0.01               <0.01 (3)

    Milk stage                                                        0             <0.01 - 0.16         0.04 (7)
    cob                                                               3             <0.01 - 0.07         0.03 (3)
                                                                      7             <0.01 - 0.01        <0.01 (5)
                                                                     14             <0.01               <0.01 (3)
                                                                     21             <0.01               <0.01 (5)

    Milk stage                                                        0              0.19 - 1.69         0.84 (7)
    husk                                                              3              0.05 - 0.98         0.64 (3)
                                                                      7              0.27 - 0.56         0.41 (3)
                                                                     14             <0.01 - 0.56         0.25 (3)
                                                                     21             <0.01 - 0.09         0.04 (5)

                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Dry Forage                                                       52/64          <0.01 - 0.13         0.07 (3)

    Dry kernel                                                       52/64          <0.01               <0.01 (3)

    Dry cob                                                          52/64          <0.01               <0.01 (3)

    Dry husk                                                         52/64          <0.01 - 0.04         0.02 (3)

    Sorghum             560 g/ha       3              USA                                                              MOBAY
    Forage                                                            7              1.88 - 2.63         2.26 (2)      41027,
                                                                     14-16           0.15 - 2.59         0.70 (11)     41028,
                                                                     21              0.13 - 0.66         0.41 (3)      41031,
                                                                     28-31           0.09 - 0.22         0.16 (8)      41055,
                                                                     55              0.09 - 0.18         0.14 (3)      43449,
                                                                     42/45           0.04 - 0.16         0.12 (7)      46356,
                                                                                                                       46357,
    Grain                                                             7              0.24 - 0.31         0.28 (2)      46545,
                                                                     14/15           0.05 - 3.00         0.88 (7)      46547,
                                                                     20/21           0.03 - 1.10         0.58 (4)      46549,
                                                                     28             <0.01 - 1.11         0.41 (4)      46550,
                                                                     35              0.03 - 0.86         0.38 (5)      46553,
                                                                     42/45           0.02 - 0.62         0.23 (8)

    Alfalfa             560 g/ha       1              USA             0              6.72 -21.2         12.47 (5)      MOBAY
                                                                      7              1.17 -18.0          5.68 (5)      51193,
                                                                     14              0.20 - 5.09         1.68 (5)      51199,
                                                                     21             <0.05 - 1.10         0.32 (5)      51200,
                                                                     28              0.58                0.58 (1)      51221,
                                                                                                                       51383

                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Beans               560 g/ha       2              USA                                                              MOBAY
    Dry beans                                                        41-48          <0.01               <0.01 (10)     54122,
                                                                     55-62          <0.01               <0.01 (10)     66523,
                                                                     69-76          <0.01               <0.01 (10)     66525,
                                                                                                                       66681,

    Dry vines                                                        41-48          <0.01- 0.12          0.02 (10)     67180
                                                                     60-62          <0.01 - 0.05         0.01 (10)     67185
                                                                     75/76          <0.01 - 0.05        <0.01 (10)

    Bush-beans          225 g/ha       3              FRG                                                              BAYER
    Beans                                                             0             <0.02 - 0.05         0.03 (2)      4819 -
                                                                      4             <0.02 - 0.05         0.03 (2)      4820/79
                                                                      7             <0.04 - 0.05        <0.04 (2)
                                                                     14             <0.04 - 0.05        <0.04 (2)
                                                                     21             <0.04 - 0.05        <0.04 (2)

    Pods                                                              0              0.04 - 0.06         0.05 (2)
                                                                      4              n.d. - <0.04       <0.04 (2)
                                                                      7              n.d. - <0.04       <0.04 (2)
                                                                     14              n.d. - <0.04       <0.04 (2)
                                                                     21              n.d. - <0.04       <0.04 (2)

    Straw                                                             0              1.83 - 2.09         1.96 (2)
                                                                      4              0.1 - 0.76          0.43 (2)
                                                                      7              0.04 - 0.24         0.14 (2)
                                                                     14              0.04                0.04 (2)
                                                                     21             <0.03 - 0.04        <0.05 (2)
                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Pole-beans          300 g/ha       3              FRG             0             <0.04 - 0.56         0.29 (2)      BAYER
                                                                      4             <0.04 - 0.41         0.22 (2)      4821 -
                                                                      7             <0.04 - 0.25         0.14 (2)      4822/79
                                                                     14             <0.04 - 0.07         0.05 (2)
                                                                     21             <0.04               <0.04 (2)

    Peas                150 -          2-3            FRG                                                              BAYER
    Peas and pods       225 g/ha                                      0              0.08 - 0.32         0.19 (3)      4856 -
                                                                                                                       4858/75
    Peas                                                              0             <0.05 - <0.06       <0.05 (2)      4811 -
                                                                      4             <0.05 - <0.06       <0.05 (2)      4812/79
                                                                      7             <0.05 - <0.06       <0.05 (2)
                                                                     14             <0.02 - 0.07        <0.05 (5)
                                                                     21             <0.02 - 0.05        <0.05 (5)
                                                                     28             <0.02 - 0.04        <0.05 (2)
                                                                     35             <0.02 - <0.04       <0.05 (2)

    Pods                                                              0             <0.05 - <0.06       <0.05 (2)
                                                                      4             <0.05 - <0.06       <0.05 (2)
                                                                      7             <0.05 - <0.06       <0.05 (2)
                                                                     14              0.02 - <0.06       <0.05 (5)
                                                                     21              0.01 - <0.06       <0.05 (5)
                                                                     28              0.01 - 0.04        <0.05 (2)
                                                                     35             <0.02 - <0.04       <0.05 (2)

    Straw                                                             0              0.40 - 2.32         1.66 (3)
                                                                     14             <0.05 - <0.06       <0.05 (2)
                                                                     21             <0.05               <0.05 (1)
                                                                     35              0.01 - <0.04        0.02 (2)
                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Cucumbers           150 g/ha       3              FRG             0             <0.02 - <0.05       <0.02 (3)      BAYER
                                                                      1             <0.02 - <0.05       <0.02 (3)      4813 -
                                                                      4             <0.04 - 0.06        <0.04 (3)      4815/79
                                                                      7             <0.04 - <0.05       <0.04 (3)
                                                                     14             <0.04 - <0.05       <0.04 (3)

    Kale                150 g/ha       2              FRG             0              1.69 - 3.48         2.59 (2)      BAYER
                                                                      7             <0.06 - 0.28         0.16 (2)      4809 -
                                                                     14             <0.05 - 0.10         0.06 (2)      4810/79
                                                                     21             <0.05 - 0.09         0.06 (2)
                                                                     28              n.d. - <0.05       <0.05 (2)

    Brussels            250 g/ha       1              NL             29              n.d.                n.d. (2)      BAYER
    sprouts                                                                                                            4808 -
                                                                                                                       4809/78

                        560 g/ha       3              USA             0              0.24 - 2.75         1.42 (5)      MOBAY
                                                                      3/4            0.10 - 1.62         0.77 (5)      68695,
                                                                      7              0.06 - 0.96         0.46 (4)      &9177,
                                                                     10              0.02 - 0.47         0.26 (5)      82487 -
                                                                     14/17           0.02 - 0.71         0.31 (5)      82489

    Cauliflower         150 g/ha       2              FRG                                                              BAYER
    Heads                                                             0             <0.03 - <0.05       <0.05 (2)      4810 -
                                                                      7             <0.03 - <0.05       <0.05 (2)      4812/76
                                                                     14             <0.03 - <0.05       <0.06 (2)      4805 -
                                                                     21             <0.03 - <0.05       <0.05 (2)      4806/79
                                                                     28             <0.03 - <0.05       <0.05 (2)

                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Stalks                                                            0             <0.02 - <0.05       <0.05 (2)
                                                                      7             <0.02 - <0.05       <0.05 (2)
                                                                     14             <0.02 - <0.05       <0.05 (2)
                                                                     21             <0.02 - <0.05       <0.05 (2)
                                                                     28             <0.02 - <0.05       <0.05 (2)

    Cauliflower,                                                      0              0.08 - 0.21         0.17 (3)
    total                                                             7             <0.01 - 0.01        <0.01 (3)
                                                                     14             <0.01               <0.01 (3)
                                                                     21              n.d.                n.d. (3)
                                                                     28              n.d.                n.d. (3)

    White cabbage       150 g/ha       2              FRG             0              0.70                0.70 (1)      BAYER
                                                                      7             <0.04               <0.04 (1)      4805/79
                                                                     14             <0.04               <0.04 (1)
                                                                     21             <0.04               <0.04 (1)
                                                                     28             <0.04               <0.04 (1)

    Savoy Cabbage       150 g/ha       2-3            FRG             0              0.35 - 2.55         1.16 (4)      BAYER
                                                                      7              0.03 - 0.15         0.08 (3)      4827/75
                                                                     14              n.d. - 0.04        <0.04 (4)      4829/75
                                                                     21/22           n.d. - 0.05        <0.05 (4)      4850/75
                                                                     28/29           n.d.                n.d. (4)      4817/76
                                                                     36              n.d.                n.d. (1)

    Kohlrabi            150 g/ha 2     FRG                                                                             BAYER
    Tuber                                                             0              n.d. - <0.06       <0.06 (2)      4804/79
                                                                      7              n.d. - <0.06       <0.06 (2)      4800/80
                                                                     14              n.d. - <0.06       <0.06 (2)
                                                                     21              n.d. - <0.06       <0.06 (2)
                                                                     28              n.d. - <0.06       <0.06 (2)
                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

    Leaves                                                            0              0.48 - 3.59         2.04 (2)
                                                                      7             <0.06 - 0.62         0.33 (2)
                                                                     14             <0.06 - 0.22         0.13 (2)
                                                                     21              n.d. - <0.06       <0.06 (2)
                                                                     28              n.d. - <0.06       <0.06 (2)

    Leek                150 g/ha       2              FRG             0              0.29 - 0.61         0.45 (2)      BAYER
                                                                      7             <0.04               <0.04 (2)      4807 -
                                                                     14             <0.04               <0.04 (2)      4808/79
                                                                     21             <0.04               <0.04 (2)
                                                                     28             <0.04               <0.04 (2)

    Head Lettuce        150 g/ha       1              FRG             0              2.0 - 9.1           5.74 (6)      BAYER
                                                                      8              0.25 - 0.79         0.59 (6)      4800 -
                                                                     14              0.05 - 0.48         0.21 (6)      4802/75
                                                                     21              0.01 - 0.09         0.03 (6)      4824 -
                                                                     28              0.01 - 0.02         0.01 (6)      4826/75

                        560 g/ha       1-3            USA             0              8.15 - 9.58         8.87 (2)      MOBAY
                                                                      3              5.79 - 15.8         9.34 (5)      39674-
                                                                      6/7            0.16 - 12.5         4.04 (15)     39676,
                                                                     10-15           0.06 - 5.74         1.37 (25)     41156 -
                                                                     20-25          <0.01 - 2.85         0.65 (26)     41165,
                                                                     24-28          <0.04 - 1.35         0.62 (11)     67466,
                                                                     35              0.10                0.10 (1)      67478 -
                                                                                                                                 

    Table 6.  (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country        Interval,             Residue mg/kg               Report
                                       applications                  days           range               average        No.
                                                                                                                                 

                                                                     42              0.09                0.09 (1)      67480,
                                                                                                                       67483,
                                                                                                                       67653 -
                                                                                                                       67655,
                                                                                                                       67929 -
                                                                                                                       67931,
                                                                                                                       67957,
                                                                                                                       69462 -
                                                                                                                       69465

    Tomatoes            150 -          3-4            FRG             0             <0.04 - 0.12         0.09 (6)      BAYER
                        225 g/ha                                      1             <0.04 - 0.29         0.13 (6)      4803 -
                                                                      4             <0.04 - 0.05        <0.04 (5)      4805/75
                                                                      7             <0.02 - 0.19         0.08 (6)      4816 -
                                                                     14             <0.04 - 0.11         0.07 (6)      4818/79

    Bulb onions         840 g/ha       3-4            USA            30/31          <0.01 - 0.02        <0.01 (11)     MOBAY
                                                                                                                       31518 -
                                                                                                                       31523,
                                                                                                                       31577 -
                                                                                                                       31579,
                                                                                                                       31632,
                                                                                                                       31691

    Peppers             560 g/ha       2              USA             0              n.d - 4.9           0.7 (9)       MOBAY
                                                                      2-4            0.1 - 1.6           0.4 (9)       18311 -
                                                                      6/7            n.d. - 2.(]         1.0 (2)       18317
                                                                     14              0.2 - 0.7           0.5 (2)       18329,
                                                                                                                       18330
                                                                                                                                 

    Table 6.  (continued)

      Residues calculated as demeton-S-methyl

    * Residues calculated as demeton-S-methyl sulphoxide

      Values in parentheses indicate number of individual results.

    Table 7. Residues from the use of Demeton-S-methyl sulphone in trials on various crops

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country                              Residue mg/kg               Report
                                       applications                  Interval,      range               average        No.
                                                                     days
                                                                                                                                 

    Apples              0.015 %        4-6            FRG             0             0.21 - 0.89          0.43 (7)      BAYER
                                                                     10            <0.01 - 0.33          0.16 (3)      4201/78
                                                                     14             0.10 - 0.36          0.21 (4)      4200 -
                                                                     21            <0.01 - 0.33          0.15 (7)      4202/79
                                                                     28             n.d. - 0.47          0.12 (7)      4200 -
                                                                     35             n.d. - 0.37          0.09 (Z)      4201/82
                                                                                                                       4210/82

    Pears               0.015 %        4-5            FRG             0             0.01 - 0.49          0.29 (3)      BAYER
                                                                     10             n.d. - 0.25          0.13 (3)      4203 -
                                                                     21             n.d. - 0.09          0.05 (3)      4204/82
                                                                     28             n.d. - 0.07          0.04 (3)      4211/82
                                                                     35             n.d. - 0.06          0.03 (3)

    Strawberries        0.015 %        4-5            FRG            25             0.05 - 0.06          0.06 (2)      BAYER
                                                                     28             0.02 - 0.04          0.03 (3)      459 -
                                                                     34             0.01 - 0.02          0.02 (3)      461/73
                                                                     41             n.d.                 n.d. (3)

    Currants, black     0.015 %        3              FRG             0             1.24 - 2.53          1.82 (3)      BAYER
                                                                      7             0.84 - 1.33          1.10 (3)      4203 -
                                                                     14             0.46 - 0.55          0.49 (3)      4205/76
                                                                     21             0.29 - 0.59          0.43 (3)
                                                                     28             0.15 - 0.22          0.18 (3)
                                                                     35             0.05 - 0.10          0.08 (3)

                                                                                                                                 

    Table 7. (continued)

                                                                                                                                 

    Crops               Dose a.i.      No. of         Country                              Residue mg/kg               Report
                                       applications                  Interval,      range               average        No.
                                                                     days
                                                                                                                                 

    Currants, red       0.015 %        3              FRG             0             0.42 - 1.02          0.70 (3)      BAYER
                                                                     21             0.07 - 0.54          0.23 (3)      4203-
                                                                     28             0.04 - 0.32          0.13 (3)      4205/75
                                                                     35             0.03 - 0.12          0.06 (3)
                                                                     42             0.04 - 0.14          0.07 (3)

    Cherries            0.015 %        3              FRG             0             1.58 - 2.33          2.00 (3)      BAYER
                                                                     14             0.69 - 1.06          0.78 (3)      4204 -
                                                                     21             0.37 - 0.55          0.45 (3)      4206/78
                                                                     28             0.19 - 0.22          0.20 (3)
                                                                     35             0.14 - 0.27          0.19 (3)

    Plums               0.015 %        5              FRG             0             0.04 - 1.1           0.54 (5)      BAYER
                                                                     14             0.05 - 1.6           0.44 (5)      4202 -
                                                                     21             0.07 - 0.57          0.25 (5)      4203/78
                                                                     28             0.05 - 0.56          0.25 (5)      4203 -
                                                                     35             0.04 - 0.54          0.22 (5)      4205/79

    Grapes              0.015 %        3              FRG             0             0.13 - 2.14          0.92 (7)      BAYER
                                                                     35             0.04 - 0.85          0.34 (7)      4207/77
                                                                     42             0.03 - 0.34          0.17 (7)      4207 -
                                                                     49             0.03 - 0.26          0.14 (7)      4210/78
                                                                     56             0.02 - 0.34          0.13 (7)      4206 -
                                                                     63             0.02 - 0.17          0.10 (2)      4207/79

    Must                                                             49-63          0.01 - 0.48          0.09 (8)

    Wine                                                             49-65          0.01 - 0.5           0.11 (8)
                                                                                                                                 

    Residues calculated as demeton-S-methyl
    Values in parentheses indicate number of individual results.
    

         Demeton-S-methyl sulphone was not found to be degradable by
    direct irradiation in the environment, (Wilmes 1982).

         In a study of the soil thin-layer mobility of 24 pesticides on
    six different soil types ranging from a non-adsorptive sand to a 
    fine-textured clay, oxydemeton-methyl showed a relatively high
    mobility related to its relatively high solubility in water (Thornton
    et al, 1976).

         Oxydemeton-methyl (methoxy-14C) was incubated at 23C for 60
    days with a silt loam and a loamy soil. Seventy-five and 79% of the
    radioactivity was recovered as 14CO2 during that period,
    respectively. Only 1% of the activity was organosoluble at that time.
    Small amounts of residue were associated with water-soluble and
    mineral residues, and with humic and fulvic acids. Most of the fulvic
    acid residues was dializable (Houseworth and Tweedy, 1974). 
    Oxydemeton-methyl was extensively degraded on silt under aerobic
    conditions, as shown by the generation of large amounts of 14CO2
    from both the ethylene- and the methoxy-label (59% and 79% after 57
    and 49 days respectively). Nearly all of the remaining 14C from each
    label was unextractable. The degradation of the parent compound under
    anaerobic conditions was also fast (half-life of less than one day),
    but was not complete since after 57 days 24% of the 14C was still
    extractable while only 8% appeared as 14CO2. Four water-soluble soil
    metabolites were identified together with five organosoluble
    metabolites. Metabolic pathways are shown in Figure 1 (Phul and
    Hurley, 1978).

         Oxydemeton-methyl is degraded by Pseudomonas putida 1453 by
    cleavage of the thioester bond to form three major compounds:
    2-(ethylsulphinyl) ethanethiol, 2-(ethylsulphonyl) ethanethiol and
    bis/-2-(ethylsulphinyl) ethyl/disulphide. Nocardia sp. DSM 43252
    converts the insecticide into another three metabolites:
    bis/-2-(ethylsulphonyl)ethyl-disulphide,bis-2-(ethylsulphinyl
    ethyl-sulphide, and bis-2-(ethylsulphonyl)ethyl-sulphide, via
    oxidation, elimination and hydrolysis. 0,0-Dimethyl phosphorothioate
    had been detected in the aqueous layer of the medium (Ziegler et
    al, 1980).

         Twenty-eight days after the application of 
    -ethylene-1-14C-demeton-S-methyl sulphone to soil (standard soil 1,
    type 2.2 as specified in BBA (Federal Biological Agency) Bulletin No.
    36, 2nd edition, 30% of the 14C activity was seen to have been
    eliminated as 14CO2.

         The following transformation products of demeton-S-methyl
    sulphone representing intermediates in mineralization, were isolated
    and identified by nuclear magnetic resonance spectroscopy and mass
    spectrometry.

         2-Ethylsulphonylethane sulphonic acid (VI) was identified as the
    main transformation product of demeton-S-methyl sulphone in soil. The
    concentration of this highly polar compound increased continuously
    with time, reaching a maximum of 10.8% of the applied radioactivity
    after 73 days. The markedly less polar 2-ethylsulphonylethanethiol
    (IV), soluble in water and methanol, accounted for up to 3.7%.

         The highly polar compound (II) peaked at a concentration of 4.9%
    after 31 days. After 126 days, it was still detectable at a
    concentration of 1.9%/(III) was detectable only in very small amounts
    (<1%).

         The relatively non-polar oxidation product of IV, the disulphide
    (V), reached a maximal concentration of 2.2% after 73 days. After 126
    days, it was detectable only in very small amounts (0.66%). A 
    non-polar degradation product VII (1.1% of the applied 14C) could not
    be identified.

         In comparison with the 14CO2 balance study, the experiments to
    identify the structures of the degradation products were conducted
    with substantially higher parent compound concentrations. It is known
    that a highly increased parent compound concentration may lead to
    delayed mineralization. On the other hand, this frequently results in
    an accumulation of intermediates which under "normal" reaction
    conditions can be detected only with difficulty or perhaps not at all.
    Figure 2 shows the probable pathways of demeton-S-methyl sulphone
    degradation in soil (Wagner and Oehlmann, 1980). To study the effects
    of plant growth and time on residues of 14C oxydemeton-methyl in
    soil, corn and cotton were grown in [14C] oxydemeton-methyl treated
    soil and harvested. After the soil had lain fallow, alfalfa and corn
    were grown in the treated soil, a portion of which had been extracted
    with methanol/water, and subsequently harvested.

         [14C] oxydemeton-methyl treated soils contained 16% of the
    radioactivity as residue when the initial corn and cotton plants were
    harvested. These plants absorbed 1.2% of the applied material. Soils
    still contained 13% of the radioactivity(all was bound) one year after
    treatment. Rotational crops of alfalfa and corn, grown in extracted
    14C. No significant difference in residue uptake was detected between
    plants grown in extracted and non-extracted soil (Shaw II, 1975).

    RESIDUES IN FOOD IN COMMERCE OR AT CONSUMPTION

    United Kingdom, 1982

         Samples of lettuce taken at the point of retail sale (July
    1981 - April 1982) were analysed, using a multi-residues procedure.
    The limit of determination of demeton-S-methyl (as the sulphone) was
    0.01 mg/kg and the recovery 80%. Results are shown in Table 8.

    Table 8.  Residues of demeton-S-methyl in lettuce at point of retail
              sale.

                                                                         

                        Total number    Residues range      Number in
                        analysed            mg/kg           range
                                                                         

    Home-grown(UK)       65                 < 0.1            56
                                        0.1 - 0.5             5
                                        0.5 - 1.0             3
                                        2.6                   1

    Imported            101                 < 0.1           101
                                                                         
                        166                                 166
                                                                         


         A further 47 samples of imported lettuce (22 from The
    Netherlands, 8 from the U.S.A., 6 from Spain, 5 from Israel, 4 from
    France, 1 each from Rumania and Cyprus) were examined for a range of
    organophosphorus pesticide residues in late 1981. The modified Watts
    et al. method with oxidation step was used. Recoveries were 80-95%
    and the limit of determination less than one tenth of the MRL. No
    residues of the demeton-S-methyl group were found in these samples.

         24 samples of top fruit, obtained direct from growers in the
    UK in 1982, were examined for a range of pesticides using a 
    multi-residues procedure. Recovery of added demeton-S-methyl,
    determined as the sulphone, was 90-100%. Three samples had been
    sprayed with a demeton-S-methyl formulation and the residues data
    obtained were:

                                                                    

                         Date of      Interval between      Residues,
    Samples              harvest      last application      mg/kg
                                      and harvest (days)
                                                                    

    Apples: Discovery    20/8                  54           < 0.05
     Millers seedlings   20/8                  54           < 0.05

    Plums:               2/8                   84           < 0.05
                                                                    

         Residues data on soft fruit both from retail outlets and direct
    from growers were obtained in May-August 1982. A range of pesticides
    was analysed for, using a multi-residues procedure. The limit of
    determination was 0.05 mg/kg and recoveries were 66% and 75%. Results
    are shown in Table 9.

         Samples were also obtained direct from growers (17 strawberries,
    6 gooseberries, 14 currants, 16 berries) and only one sample (of
    gooseberries) showed detectable residue of demeton-S-methyl (0.10;
    0.25mg/kg) after 32 days between last application and harvest.

    METHODS OF RESIDUE ANALYSIS

         Hill et al. (1984) have reported a study on the experimental
    conditions for the routine quantitative determination of the
    residues of a number of organophosphorus pesticides, including
    demeton-S-methyl, following conversion to the sulphones.

    NATIONAL MAXIMUM RESIDUE LIMITS

         National MRLs, as listed in Table 10, were reported to the
    meeting (effective March 1983).

    APPRAISAL

         The meeting considered data from residue trials on a number of
    crops. In general the results of the trials support the maximum
    residue levels previously estimated in 1973 and enabled the meeting to
    estimate maximum levels for several new commodities, namely cherries
    (1 mg/kg), kale (0.2), bulb vegetables (0.1, tomatoes (0.2) and
    peppers (1).

         The meeting proposed a group GL of 0.2 mg/kg for brassica leafy
    vegetables to replace separate GLs of 0.2 mg/kg for broccoli, Brussels
    sprouts, cabbage, cauliflower and kale. The commodity description of
    cereals ("raw cereals") was redefined as "cereal grains."


        Table 9.  Demeton-S-methyl residues in retail samples of soft fruit

                                                                                              

    Fruit                                   Number of samples    Residues mg/kg
                                            examined
                                                                                              

    Strawberries (UK-produced)                   23              one 0.16; one 0.79;
                                                                 others not detectable (ND)
    Strawberries (imported)                      18                    ND
    Gooseberries (UK)                             8                    ND
    Black/red currants (UK)                      13                    ND
    Berries (raspberries, loganberries,
    blackberries) (UK)                           15                    ND
                                                                                              

    Table 10.  National Maximum Residue Limits

    Oxydemeton-methyl

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Australia 1)             cereals                                        0.5
                             herbs                                          0.5
                             hops                                           0.5
                             macadamia nuts                                 0.05    2)
                             oil seed                                       0.5
                             pome fruit                                     0.5
                             stone fruit                                    0.5
                             strawberries                                   0.5
                             tomatoes                                       0.5
                             vegetables                                     0.5

                             water                                          0.03

    Austria                  cereals                        35              0.4     3)
                             fruit                          35              0.4     3)
                             potatoes                       35              0.2     3)
                             sugar beets                    35              0.4     3)
                             vegetables (excl.              35              0.4     3)
                             carrots)

                             other crops                                    0.05    3)

    Belgium                  carrots                        28              0       3)
                             fruit (excl. citrus)           28              0.4     3)
                             potatoes                       28              0.1     3)
                             sugar beets                    28
                             vegetables (excl.              28              0.4     3)
                             carrots)

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Brazil 3)                apples                                         1.0
                             barley                                         0.2
                             cotton                                         0.2
                             cucumbers                                      0.2
                             eggplants                                      0.2
                             maize                                          0.2
                             melons                                         0.2
                             oats                                           0.2
                             peaches                                        1.0
                             pears                                          0.5
                             plums                                          1.0
                             potatoes                                       0.2
                             pumpkins                                       0.2
                             quinces                                        0.5
                             rice                                           0.2
                             rosemallow                                     0.05    2)
                             rye                                            0.2
                             sorghum                                        0.2
                             tomatoes                                       0.5
                             wheat                                          0.2

                             eggs (shell-free)                              0.05    2)
                             meat                                           0.05    2)
                             milk                                           0.05    2)

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Canada                   barley                                         0.1     2)
                             beans                                          0.1     2)
                             brassicas                                      0.1     2)
                             caneberries                                    0.1     2)
                             cucumbers                                      0.1     2)
                             maize                                          0.1     2)
                             melons                                         0.1     2)
                             oats                                           0.1     2)
                             peas                                           0.1     2)
                             potatoes                                       0.1     2)
                             pumpkins                                       0.1     2)
                             strawberries                                   0.1     2)
                             sugar beets                                    0.1     2)
                             turnips                                        0.1     2)
                             wheat                                          0.1     2)

    Cyprus                   citurs fruit                   20
                             grapes                         20
                             pome fruit                     20
                             potatoes                       20
                             stone fruit                    20
                             vegetables                     20

    Denmark                  general 4)                     28

    European                 carrots                                        0
    Community 5)             other crops                                    0.4

    Finland                  fodder crops                                   0.4     7)
                             food crops                                     0.4     7)
                             fruit                          35
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    France                   beets                          21
                             carrots                                        0       6)
                             cereals                        21
                             fruit                          21              0.4     6)
                             grapes                         21
                             vegetables (excl.                              0.4     6)
                             carrots)

    Germany,                 berry fruit (excl.             21/28  8)
    Federal Republic         strawberries)
                             brassicas (excl.               21
                             cabbage)
                             cabbage                        14/21  8)       0.5     3)
                             carrots                        21
                             cereals                        21              0.2     3)
                             currants                                       2.0     3)
                             field beans                    21              0.5     3)
                             fodder beets                   28
                             fruiting vegetables             4
                             grapes                         42/60  8)       2.0     3)
                             hops                           21              0.05    3)

                             legume vegetables (excl.        7              0.5     3)
                             field beans)
                             lettuce                        14
                             leafy vegetables               14              0.5     3)
                             peaches                        28              1.0     3)
                             plums                          28              1.0     3)
                             pome fruit                     28              1.0     3)
                             potatoes                       14/21  8)       2.0     3)
                             root vegetables                21
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             stem vegetables                14              0.5     3)
                             stone fruit                    28              0.5     3)
                             sugar beets                    28              0.1     3)
                             tobacco                         7
                             vegetables (excl.                              0.5     3)
                             carrots)

                             other fruit                                    0.5     3)
                             other food crops                               0.05    3)

    Great Britain            apples, apricots, beans,
                             blackberries, brassicas,
                             carrots, celery, cereals
                             (excl. barley and wheat)
                             cherries, cucumbers (under
                             glass), currants (black,
                             red and white), fodder
                             beets, gooseberries,
                             lettuce (under glass),
                             log anberries, mangels,
                             nuts, parsnip, peaches,
                             Dears, Deas, plums (incl.
                             damsons), potatoes,
                             raspberries, strawberries,
                             sugar beets,, tomatoes
                             (under glass)                  21

                             barley, pastures, wheat        14

                             fodder beets (silage),
                             mangels (silage)               10
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    India                    coffee, cotton                 25
                             mangoes, peanuts               30

    Israel                   almonds, apples, beans,
                             brassicas, citrus
                             fruit, cotton,
                             cucumbers, eggplants,
                             fruit, grapes, melons,
                             peas, peppers, potatoes,
                             pumpkins, sugar beets,
                             tomatoes, zucchinis            21

    Italy                    carrots                        20
                             fruit                          20              0.4     9)
                             vegetables (excl.              20              0.4     9)
                             carrots)

    Japan                    apples                         30

    Luxembourg 5)            carrots                         0.05
                             cereals                         0.2
                             currants                        2.0
                             grapes                          2.0
                             plums                           1.0
                             pome fruit                      1.0
                             potatoes                        0.2
                             vegetables (excl.               0.5
                             carrots)

                             other fruit                     0.5
                             other food crops                0.05
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              
    Mexico                   alfalfa                        14/21  8)       5.0
                             apples                         30              1.0
                             beans (green)                  21              0.5
                             broccoli                        7              1.0
                             Brussels sprouts               24
                             cabbage                         7              1.0
                             cantaloupes                    14              0.3
                             cauliflowers                    7/14  8)
                             chick peas                     21              0.3
                             chilli                         14
                             citrus fruit                   30
                             cucumbers                      14              1.0
                             eggplants                       7/14  8)       1.0
                             grades                         30/90  8)       0.1
                             kale                           24
                             lettuce                        14              2.0
                             maize                           7/14 8)        0.5
                             melons (excl.                  14
                             watermelons )
                             onions                         30              0.05
                             oranges                         7              1.0
                             pears                          30              0.3
                             pecans                         30              0.3
                             peppers                                        0.75
                             plums                          30
                             potatoes                        7              0.1
                             pumpkins                       14              1.0
                             safflowers                      7              1.0
                             sorghum                        45              0.75
                             strawberries                   14              2.0
                             watermelons                     7              0.3
                             zucchinis                      14
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Netherlands              beans                          28              0.4     6)
                             blackberries                   28
                             broccoli                       28              0.4     6)
                             Brussels sprouts               28              0.4     6)
                             cauliflowers                   28              0.4     6 )
                             cereals                        28              0.1     6)
                             cherries                       28
                             curr ants                      28
                             kale                           28
                             peaches                        28
                             peas                           28              0.4     6)
                             plums                          28
                             potatoes                       28              0.05    6)
                             r aspb err i es                28
                             small fruit (field grown)      28              0.4     6)
                             strawberries                   28

    Pakistan                 chilli                         60
                             rape (oilcake)                 60

    Portugal                 field crops                    35
                             fruit (incl.                   35
                             strawberries)
                             pastures                       14
                             potatoes                       35
                             vegetables                     35

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              
    South Africa             apples                         21              0.4     6)
                             apricots                                       0.4     6)
                             beans                          10              0.2     6)
                             Brussels sprouts               14              0.2     6)
                             cabbage                        14              0.2     6)
                             cauliflowers                   14              0.2     6)
                             citrus fruit                   21              0.5     6)
                             cottonseed                                     0.1     6)
                             cucurbits                      21
                             eggplants                                      0.2     6)
                             maize (green)                                  0.2     6)
                             olives                                         0.1     6)
                             onions                                         0.1     6)
                             peaches                        21              0.4     6)
                             peanuts                                        0.1     6)
                             pears                          21              0.4     6)
                             peppers                                        0.2     6)
                             plums                                          0.4     6)
                             potatoes                       21              0.2     6)
                             rooibos tea                                    0.1     6)
                             sorghum                                        0.2     6)
                             tomatoes                       21              0.2     6)
                             wheat                                          0.2     6)

                             other Cruciferae               10              0.2     6)

    Spain  5)                beets                          30
                             carrots                                        0
                             cereals                        30
                             cotton                         30
                             fruit                          30              0.4
                             vegetables (excl. carrots)                     0.4
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Sweden  6)               bran                                           0.2
                             cereals                                        0.2
                             flour (cereals)                                0.1
                             fruit                                          0.4
                             oat flakes                                     0.1
                             potatoes                                       0.2
                             vegetables                                     0.4
                             wheat flakes                                   0.1

    Switzerland              fruit (excl. cherries)         42              0.4     9)
                             sugar beets                    42              0.4     9)

    Taiwan                   apples                         30

    Thailand                 bananas, citrus fruit,
                             coffee, cotton, grapes,
                             maize, mung beans,
                             peanuts, potatoes, rice,
                             sorghum, soybeans, sugar-
                             cane, tea, tobacco,
                             vegetables                     28-30

    USA                      alfalfa                        21
                             alfalfa, chaff and                            11.0
                             hay (grown for seed)
                             alfalfa, green                                 5.0
                             apples                                         1.0
                             beans                          21
                             blackberries                    7              2.0
                             broccoli                        7              1.0
                             Brussels sprouts                3              1.0
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             cabbage                         7              1.0
                             cauliflowers                    7
                             clover                         21
                             clover, chaff and                             11.0
                             hay (grown for seed)
                             clover, green                                  5.0
                             cotton                         14
                             cotton seed                                    0.1
                             cucumbers                                      1.0
                             eggplants                       7              1.0
                             filberts                      105              0.05
                             grapes                         90              0.1
                             lemons                          7              1.0
                             lettuce                        14/28  10)      2.0
                             lettuce                        21  11)         2.0
                             lima bean forage                               2.0
                             lima beans                                     0.5
                             maize (field-, sweet-,          7
                             corn, popcorn, grain
                             and forage)
                             maize (fodder and forage)                      3.0
                             maize, grain (incl.                            0.5
                             fresh corn, sweet corn,
                             kernels and cob)
                             melons                         14              0.3
                             mint                           14
                             mint hay                                      12.5
                             onions, dry bulb                               0.05
                             onions (span.)                 30
                             oranges                         7              1.0
                             peppers                                        0.75
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             pea forage                     21              2.0
                             pea hay                        21              8.0
                             pears                          30              0.3
                             peas                           21              0.3
                             plums                          35              1.0
                             potatoes                        7              0.1
                             prunes                         35
                             pumpkins                       14              0.3
                             raspberries                     7              2.0
                             safflower                       7              1.0
                             snap bean forage                               2.0
                             snap beans                                     0.5
                             sorghum (milled                                2.0
                             fraction except flour)
                             sorghum forage                 21              2.0
                             sorghum grain                  45              0.75
                             spearmint                      14
                             strawberries                    3
                             sugar beets                    30              0.3
                             sugar beet tops                30              0.5
                             summer squash                   1              1.0
                             turnips                         7              0.3
                             turnip tops                    21              2.0
                             walnuts                        30              0.3
                             winter squash                  14              0.3
                             meat, fat and meat-by-                         0.01
                             products of cattle,
                             goats, horses, pigs
                             and sheep
                             milk                                           0.01

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Yugoslavia               field crops                    28
                             fruit                          28              0.5  6)
                             grapes                         28
                             hops                           28
                             sugar beets                    28              0.5  6)

                             other food crops                               0.05  6)

    1) = Demeton including demeton-O, demeton-S, demeton-O-methyl, demeton-S-methy and 
         oxydemeton-methyl
    2) = Level at or about the limit of determination
    3) = Sum of oxydemeton-methyl, demeton-S-methyl and demeton-S-methyl sulphone expressed 
         as demeton-S-methyl
    4) = No application to crops with a short vegetation period
    5) = Sum of oxydemeton-methyl, demeton-S-methyl and demeton-S-methyl sulphone separately 
         calculated or expressed as demeton-S-methyl
    6) = Sum of oxydemeton-methyl, demeton-S-methyl and demeton-S-methyl sulphone
    7) = Preliminary
    8) = Depending on formulation
    9) = Sum of oxydemeton-methyl and demeton-S-methyl sulphone separately calculated or 
         expressed as demeton-S-methyl sulphone
    10) = In California and Arizona, depending on application rate
    11) = In other States
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    demeton-S-methyl sulphone
    (in "Gusathion MS")

    Austria 1)               cereals                                        0.2
                             fruit                                          0.4
                             potatoes                                       0.2
                             sugar beets                                    0.4
                             vegetables (excl.                              0.4
                             carrots)

                             other crops                                    0.05

    Belgium  1)              carrots                                        0
                             fruit                          42
                             fruit (excl. citrus)                           0.4
                             vegetables (excl.                              0.4
                             carrots)

    Brazil  1)               apples                                         1.0
                             barley                                         0.2
                             cotton                                         0.1
                             cucumbers                                      0.2
                             eggplants                                      0.2
                             maize                                          0.2
                             melons                                         0.2
                             oats                                           0.2
                             peaches                                        1.0
                             pears                                          0.5
                             plums                                          1.0
                             potatoes                                       0.2
                             pumpkins                                       0.2
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             quinces                                        0.5
                             rice                                           0.2
                             rosemallow                                     0.05
                             rye                                            0.2
                             sorghum                                        0.2
                             tomatoes                                       0.5
                             watermelons                                    0.2
                             wheat                                          0.2

                             eggs (shell-free)                              0.05    2)
                             meat                                           0.05    2)
                             milk                                           0.05    2)

    Denmark                  carrots                                        0.05    2)
                             cereals (raw)                                  0.2
                             fruit                                          0.5
                             grapes                                         0.5
                             potatoes                                       0.2
                             vegetables (excl.                              0.5
                             carrots)
                             other root crops                               0.5

                             animals fat                                    0.05    2)
                             eggs                                           0.05    2)
                             meat                                           0.05    2)
                             milk                                           0.05    2)
                             milk products                                  0.05    2)

    European                 carrots                                        0
    Community 3)             other crops                                    0.4

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    France                   beets                          21
                             carrots                                        0       4)
                             fruit                          21              0.4     4)
                             grapes                         21
                             pot atos                       21
                             vegetables (excl.                              0.4     4)
                             carrots)

    Germany,                 cereals                                        0.2     1)
    Federal Republic         cherries                       28              0.5     1)
                             currants                                       2.0     1)
                             grapes                         49              2.0     1)
                             peaches                                        1.0     1)
                             plums                          35              1.0     1)
                             pome fruit                     28              1.0     1)
                             potatoes                                       0.2     1)
                             prunes                         35
                             sugar beets                                    0.1     1)
                             vegetables (excl.                              0.1     1)
                             carrots)

                             other fruit                                    0.5     1)
                             other food crops                               0.05    1)

    Italy                    apples                         35
                             beets                          35
                             carrots                                        0       3)
                             citrus fruit                   35
                             fruit                                          0.4     3)
                             grapes                         35
                             peaches                        35
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             pears                          35
                             potatoes                       35
                             vegetables (excl.              35              0.4     3)
                             carrots)

    Luxembourg  5)           carrots                                        0.05
                             cereals                                        0.2
                             currants                                       2.0
                             grapes                                         2.0
                             plums                                          1.0
                             pome fruit                                     1.0
                             potatoes                                       0.2
                             vegetables (excl.                              0.5
                             carrots)

                             other fruit                                    0.5
                             other food crops                               0.05

    Netherlands  4)          beans                                          0.4
                             berry fruit (field grown)                      0.4
                             brassicas                                      0.4
                             cereals                                        0.05
                             peas                                           0.4
                             potatoes                                       0.05

    Portugal                 apples                         21
                             citrus fruit                   91
                             pastures                       14
                             pears                          21

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    South Africa  4)         apples                                         0.4
                             apricots                                       0.4
                             beans                                          0.2
                             citrus fruit                                   0.5
                             cottons eed                                    0.1
                             cruciferae                                     0.2
                             eggplants                                      0.2
                             maize (green)                                  0.2
                             olives                                         0.1
                             onions                                         0.1
                             peaches                                        0.4
                             peanuts                                        0.1
                             pears                                          0.4
                             peppers                                        0.2
                             plums                                          0.4
                             potatoes                                       0.2
                             rooibos tea                                    0.1
                             sorghum                                        0.2
                             tomatoes                                       0.2
                             wheat                                          0.2

    Spain                    carrots                                        0       3)
                             cotton                         28
                             fruit                                          0.4     3)
                             pome fruit                     28              0.4     3)
                             stone fruit                    28              0.4     3)
                             vegetables (excl.                              0.4     3)
                             carrots)

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Sweden  4)               bran                                           0.2
                             cereals                                        0.2
                             flour (cereals)                                0.2
                             fruit                                          0.4
                             oat flakes                                     0.1
                             potatoes                                       0.2

                             vegetables                                     0.4
                             wheat flakes                                   0.1

    Switzerland              fruit                          42              0.4     6)
                             sugar beets                    42              0.4     6)

    USA                      alfalfa, chaff                                11.0
                             and hay (for seed)
                             alfalfa, green                                 5.0
                             apples                                         1.0
                             blackberries                                   2.0
                             broccoli                                       1.0
                             Brussels sprouts                               1.0
                             cabbage                                        1.0
                             cauliflower                                    1.0
                             clover, chaff and                             11.0
                             hay (grown for seed)
                             clover, green                                  5.0
                             cottons eed                                    0.1
                             cucumbers                                      1.0
                             eggplants                                      1.0
                             filberts                                       0.3
                             grapefruit                                     1.0
                             grapes                                         0.1
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             lemons                                         1.0
                             lettuce, head                                  2.0
                             lima bean forage                               2.0
                             lima beans                                     0.5
                             maize, fodder and                              3.0
                             forage
                             maize, grain (incl.                            0.5
                             fresh corn, sweet corn,
                             kernels and cobs)
                             melons                                         0.3
                             mint hay                                      12.5
                             onions, dry bulb                               0.05
                             oranges                                        1.0
                             pea forage                                     2.0
                             pea hay                                        8.0
                             pears                                          0.3
                             peas                                           0.3
                             peppermint (dried)                            12.5
                             peppers                                        0.75
                             plums (fresh prunes)                           1.0
                             potatoes                                       0.1
                             pumpkins                                       0.3
                             raspberries                                    2.0
                             safflower                                      1.0
                             snap bean foraoe                               2.0
                             snap beans                                     0.5
                             sorghum forage                                 2.0
                             sorghum, grain                                 0.75
                             sorghum (milled                                2.0
                             fraction except flour)
                             squash, summer                                 1.0
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             squash, winter                                 0.3
                             strawberries                                   2.0
                             sugar beets                                    0.3
                             sugar beet tops                                0.5
                             turnips                                        0.3
                             turnip tops                                    2.0
                             walnuts                                        0.3

                             meat, fat and                                  0.01
                             meat by-products of
                             cattle, goats, horses,
                             pigs and sheep
                             milk                                           0.01

    Yugoslavia  4)           fruit                                          0.5
                             sugar beets                                    0.5

                             other food crops                               0.05

    1) = Sum of demeton-S-methyl sulphone, demeton-S-methyl and oxydemeton-methyl expressed as 
         demeton-S-methyl
    2) = Level at or about the limit of determination
    3) = Sum of demeton-S-methyl sulphone, demeton-S-methyl and oxydemeton-methyl separately 
         calculated or expressed as dEmeton-S-methyl sulphone
    4) = Sum of demeton-S-methyl sulphone, demeton-S-methyl and oxydeaeton-methyl
    5) = Sum of demeton-S-methyl sulphone, demeton-S-methyl and oxydemeton-methyl separately 
         calculated or expressed as demeton-S-methyl
    6) = Sum of demeton-S-methyl sulphone and oxydemeton-methyl separately calculated or 
         expressed as demeton-S-methyl sulphone

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Demeton-S-methyl

    Australia  1)            cereals                        21              0.5
                             cotton                         21
                             field crops                    21
                             herbs                                          0.5
                             hops                           21              0.5
                             macadamia nuts                                 0.05    2)
                             oil seed                                       0.5
                             pastures                        3
                             pome fruit                     21              0.5
                             potatoes                       21
                             rape                           21
                             root crops                     21
                             stock food                     3
                             stone fruit                    21              0.5
                             strawberries                                   0.5
                             tobacco                        21
                             tomatoes                       21              0.5
                             vegetables                     21              0.5

                             water                                          0.03

    Austria                  cereals                        35              0.4     3)
                             field crops                    35
                             fruit                          35              0.4     3)
                             grapes                         35              0.05    3)
                             potatoes                       35              0.2     3)
                             sugar beets                    35              0.4     3)
                             vegetables (excl.              35              0.4     3)
                             carrots)
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              
                             other registered                               0.05    3)
                             crops

    Belgium                  beets                          28
                             carrots                        28              0       3)
                             fruit (excl. citrus)           28              0.4     3)
                             hops                           28
                             pastures                       10
                             potatoes                       28              0.1     3)
                             vegetables (excl.              28              0.4     3)
                             carrots)

    Brazil  1)               apples                         21              1.0
                             barley                         21              0.2
                             cotton                         14              0.2
                             cucumbers                      21              0.2
                             eggpl ants                     21              0.2
                             maize                          21              0.2
                             melons                         21              0.2
                             oats                           21              0.2
                             peaches                        21              1.0
                             pears                          21              0.5
                             plums                          21              1.0
                             potatoes                        7              0.2
                             pumpkins                       21              0.2
                             quinces                        21              0.5
                             rice                           21              0.2
                             rosemallow                     21              0.05
                             rye                            21              0.2
                             sorghum                        21              0.2
                             tomatoes                       21              0.5
                             wheat                          21              0.2
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             eggs (shell-free)                              0.05    2)
                             meat                                           0.05    2)
                             milk                                           0.05    2)

    France                   carrots                                        0       6)
                             fruit                                          0.4     6)
                             vegetables (excl.                              0.4     6)
                             carrots)

    Germany,                 cereals                                        0.2     3)
    Federal Republic         currants                                       2.0     3)
                             fodder beets                   28
                             grapes                                         2.0     3)
                             peaches                                        1.0     3)
                             plums                                          1.0     3)
                             pome fruit                                     1.0     3)
                             potatoes                       14              2.0     3)
                             sugar beets                    28              0.1     3)
                             vegetables (excl.                              0.5     3)
                             carrots

                             other fruit                                    0.5     3)
                             other food crops                               0.05    3)

    Great Britain            apples, apricots, beans,
                             beetroot, blackberries,
                             brassicas, carrots,
                             celery, cereals (excl.
                             barley and wheat),
                             cherries, cucumbers
                             (under glass), currants
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             (black, red and white),
                             fodder beets, goose-
                             berries, lettuce (field
                             grown, and under glass),
                             loganberries, mangels,
                             nuts, parsnip, peaches,
                             Dears, peas, plums,
                             potatoes, raspberries,
                             strawberries, sugar beets,
                             tomatoes (under glass)         21
                             barley, pastures, wheat        14
                             fodder beets (silage),         10
                             mangels (silage)

    Hungary                  general                        30              0.5

    Israel                   apples                                         1.0
                             blueberries                                    2.0
                             beans                                          0.2
                             brassicas                                      0.2
                             broccoli                                       0.2
                             cereals                                        0.2
                             citrus fruit                                   0.5
                             cottons eed                                    0.1
                             eggplants                                      0.2
                             fodder                                         5.0
                             forage                                        10.0
                             grapes                                         2.0
                             lettuce                                        0.5
                             peaches                                        1.0
                             pears                                          0.5
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             peas                                           0.2
                             peppers                                        0.2
                             plums                                          1.0
                             potatoes                                       0.2
                             pumpkins                                       0.2
                             strawberries                                   0.5
                             sugar beets                                    0.1
                             tomatoes                                       0.2
                             zucchinis                                      0.5

                             eggs (shell-free)                              0.05
                             meat and fat of                                0.05
                             cattle, pigs,
                             poultry and sheep
                             milk                                           0.05
                             milk products                                  0.05

    Italy                    carrots                        20              0       4)
                             fruit                          20              0.4     4)
                             vegetables (excl.              20              0.4     4)
                             carrots )

    Luxembourg  7)           carrots                                        0.05
                             cereals                                        0.2
                             currants                                       2.0
                             grapes                                         2.0
                             plums                                          1.0
                             pome fruit                                     1.0
                             potatoes                                       0.2
                             vegetables (excl.                              0.5
                             carrots)
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             other fruit                                    0.5
                             other food crops                               0.05

    Netherlands  5)          beans                                          0.4
                             berry fruit (field grown)                      0.4
                             brassicas                                      0.4
                             cereals                                        0.5
                             peas                                           0.4
                             potatoes                                       0.05

    New Zealand              alfalfa                        7
                             apples                         21/35  8)
                             broad beans                    21/35  8)
                             Brussels sprouts               21/35  8)
                             cabbage                        21/35  8)
                             cauliflower                    21/35  8)
                             cereals                        21/35  8)
                             cocksfoot                      21/35  8)
                             currants                       21/35  8)
                             (red and black)
                             marrow stemmed                 21/35  8)
                             pastures                       14
                             pears                          21/35  8)
                             potatoes                       21/35  8)
                             rape                           21/35  8)
                             raspberries                    21/35  8)
                             strawberries                   21/35  8)
                             turnips                        21/35  8)

                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

    Norway                   berry fruit                    28  9)
                             cereals                        28  9)
                             pome fruit                     28  9)

    Peru                     citrus fruit                   28
                             cucurbits                      28-42
                             wheat                          14

    Poland                   apples, carrots,
                             cauliflower, cherries
                             (excl. early species),
                             curly kale, dill,
                             mustard, peaches, pears,
                             peas, plums, raspberries,
                             rutabagas, spinach,
                             strawberries                   42              0.4

                             carrots (animal feed),
                             field beans, fodder
                             beets, hops, peas
                             (animal feed), potatoes,
                             rape, sugar beets,
                             tobacco                        42

                             fruit, vegetables                              0.4

    South Africa  5)         apples                         21              0.4
                             apricots                       21              0.4
                             beans                          10              0.2
                             citrus fruit                                   0.5
                             cotton (as feed stuff)         21              0.1
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             cotton (harvest)                5
                             cruciferae                     10-14           0.2
                             eggplants                      21              0.2
                             maize                          21              0.2
                             maize (green)                                  0.2
                             olives                         90              0.1
                             onions (green)                 21              0.1
                             peaches                        21              0.4
                             peanuts                        21              0.1
                             pears                          21              0.4
                             peas                           21
                             peppers                        14              0.2
                             plums                          21              0.4
                             potatoes                       21              0.2
                             rooibos tea                                    0.1
                             sorghum                        21              0.2
                             tomatoes                       21              0.2
                             wheat                          21              0.2

    Spain  4)                carrots                                        0
                             fruit                                          0.4
                             vegetables (excl.                              0.4
                             carrots)

    Sweden  5)               bran                                           0.2
                             cereals                        28              0.2
                             flour (cereals)                                0.1
                             fruit (incl.                   28              0.4
                             berry fruit)
                             oat flakes                                     0.1
                                                                                              

    Table 10.  (continued)

                                                                                              

    Country                  Crop/Commodity                Safety         MRL
                                                           intervals      (mg/kg)
                                                           (days)
                                                                                              

                             potatoes                       28              0.2
                             vegetables (incl.              28              0.4
                             root vegetables)
                             wheat flakes                                   0.1

    Yugoslavia  5)           fruit                                          0.5
                             sugar beets                                    0.5
                             other food crops                               0.05
                                                                                              
    

    RECOMMENDATIONS

         The following maximum residue levels are recorded as suitable for
    use as guideline levels.

                                                                       

                                     GL             Interval on which
                                   (mg/kg)            GLs are based
                                                         (days)
                                                                       

    cherries                          1                    35
    bulb vegetables                   0.1                  21
    brassica leafy vegetables         0.2                  21
    tomatoes                          0.2                  3
    peppers                           1                    14
    cereal grains                     0.2 (replacing "raw cereals" at 
                                          the same level)
                                                                       

    REFERENCES

    Hill, A.R.C., Wilkins, J.P.G. Findlay Nina, R.I. and Lontay Karen E.M.
    1984      Organophosphorus sulphides, sulphoxides and sulphones. Part
              1. Determination of Residues in Fruit and Vegetables by Gas-
              Liquid Chromotography. Analyst 109 483.

    Houseworth, L.D., Tweedy, B.G. : The metabolism of METASYSTOX-R in
    1974      soil. Mobay Report No. 39219.

    Nichols, S.S., Thornton, J.S. Photodecomposition of METASYSTOX-R in
    1978      aqueous solution and on silt loam soil. Mobay Report No.
              54412.

    Phul, R.J., Hurley, J.B. The aerobic and anaerobic soil metabolism of
    1978      METASYSTOX-R. Mobay Report No. 63056.

    Shaw, H.R., II: Determination of soil-bound residues and uptake by
    1975      rotational crops from soil treated with METASYSTOX-R. Mobay
              Report No. 43971, (revised, April 11, 1975).

    Thornton, J.S. The effects of feeding METASYSTOX-R to chickens. Mobay
    1975      Report No. 46081.

    Thornton, J.S., Hurley, J.B., Obrist, J.J.: Soil thin-layer mobility
    1976      of twenty-four pesticide chemicals. Mobay Report No. 51016.

    Wagner, K., Oehlmann, L. Metabolism of demeton-S-methyl sulphone in
    1980      soil. Bayer AG, PF-A/CE-MR unpublished Report RA-170.

    Wilmes, R. Orientating Studies on Stability to Light. Bayer AG, PF-A/
    1982      CE-PIQ-ENA.

    Ziegler, W., Engelhardt, G. Wallnofer, P.R., Oehlmann, L. Wagner, K.
    1980      Degradation of Demeton-S-Methyl Sulphoxide (Metasystox R) by
              Soil Micro-organisms. J. Agric. Food Chem. 28, 1102 - 1106.


    See Also:
       Toxicological Abbreviations
       Demeton-S-methyl and related compounds (WHO Pesticide Residues Series 3)
       Demeton-S-Methyl and Related Compounds (Pesticide residues in food: 1989 evaluations Part II Toxicology)