International Agency for Research on Cancer (IARC) - Summaries & Evaluations
CHLOROMETHYL METHYL ETHER
VOL.: 4 (1974) (p. 239)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Chloromethyl methyl ether (CMME) is almost invariably contaminated by
bis(chloromethyl)ether (BCME), and the latter may be responsible for
at least part of the observed carcinogenic activity. Such contaminated
CMME has been found to be carcinogenic on subcutaneous injection in
the mouse and possibly to be an initiator for mouse skin tumours.
Inhalation in mice and subcutaneous injection in the rat produced
equivocal evidence of carcinogenic activity.
5.2 Human carcinogenicity data
One study based on 4 cases of oat cell lung cancer observed amongst
111 workers exposed to CMME (and its associated BCME impurity),
followed for 5 years, suggests an increased risk of lung cancer.
Subsequent evaluation: Suppl. 7 (1987)
Last updated: 17 March 1998