VOL.: 32 (1983) (p. 225)
Chem. Abstr. Name: Benzo(e)pyrene
Multiple intraperitoneal administrations of benzo[e]pyrene to newborn mice did not result in a significant increase of tumours in two studies.
In rats, pulmonary injection of benzo[e]pyrene at various dose levels resulted in one squamous-cell carcinoma of the lung at the highest dose level and one pulmonary sarcoma at the mid-dose level.
No data on the teratogenicity of this chemical were available.
Benzo[e]pyrene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. It did not induce mitotic recombination in yeast. It did not induce mutations or sister chromatid exchange in cultured mammalian cells and was negative in assays for morphological transformation. It induced unscheduled DNA synthesis in HeLa cells in the presence of an exogenous metabolic system, but not in primary rat hepatocytes. In the one available report, it did not induce chromosomal aberrations in vitro. In the one available in-vivo study, it induced sister chromatid exchange, but not chromosomal aberrations in hamster bone marrow.
There is limited evidence that benzo[e]pyrene is active in short-term tests.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)
See Also: Toxicological Abbreviations