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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DIBENZ(a,h)ACRIDINE

VOL.: 3 (1973) (p. 247)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

In mice, painting with dibenz(a,h)acridine induces skin tumours. Subcutaneous administration to mice induced local sarcomas and increased the incidence of lung tumours. It has not been tested adequately by other routes in the mouse and not at all in other species.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on the significance of dibenz(a,h)acridine exposure to man are available. However, coal-tar and other materials which are known to be carcinogenic to man may contain dibenz(a,h)acridine. The substance has also been detected in other environmental situations. The possible contributions of heterocyclic compounds from some environmental sources to the overall carcinogenic risk to man is discussed in the General Remarks.

Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 61: Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 16 March 1998






















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