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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DIBENZ(a,j)ACRIDINE

VOL.: 3 (1973) (p. 254)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Dibenz(a,j)acridine induced skin tumours in mice following topical application and produced local sarcomas at the highest dose tested following subcutaneous administration. It increased the incidence of lung tumours after s.c. administration. Negative results were obtained by the oral route in mouse, but the test was inadequate because of the small number of animals. It has not been tested in other species.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on the significance of dibenz(a,j)acridine exposure to man are available. However, coal-tar and other materials which are known to be carcinogenic to man may contain dibenz(a,j)acridine. The substance has also been detected in other environmental situations. The possible contribution of heterocyclic compounds from some environmental sources to the overall carcinogenic risk to man is discussed in the General Remarks.

Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 61: Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 16 March 1998






















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