International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 3 (1973) (p. 254)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Dibenz(a,j)acridine induced skin tumours in mice following topical application
and produced local sarcomas at the highest dose tested following
subcutaneous administration. It increased the incidence of lung
tumours after s.c. administration. Negative results were obtained by
the oral route in mouse, but the test was inadequate because of the
small number of animals. It has not been tested in other species.
5.2 Human carcinogenicity data
No case reports or epidemiological studies on the significance of
dibenz(a,j)acridine exposure to man are available. However, coal-tar and other
materials which are known to be carcinogenic to man may contain
dibenz(a,j)acridine. The substance has also been detected in other
environmental situations. The possible contribution of heterocyclic
compounds from some environmental sources to the overall carcinogenic
risk to man is discussed in the General Remarks.
Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 61: Group 2B)
For definition of Groups, see Preamble Evaluation.
Last updated: 16 March 1998