International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 12 (1976) (p. 85)
CAS No.: 97-77-8
Chem. Abstr. Name: Tetraethylthioperoxydicarbonic diamide
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Disulfiram (of rubber-processing grade) was tested by oral
administration and by single subcutaneous injection in two strains of
mice. When given by the oral route it increased the incidence of
liver-cell tumours and caused a slight increase in the number of lung
tumours in males of one strain but not in those of the other.
These results are derived from a study in which an impure material was
tested. Studies on pharmaceutical grade material are now underway in a
number of laboratories (IARC Information Bulletin No. 6).
The limited data available do not allow an evaluation of the
carcinogenicity of disulfiram to be made.
Disulfiram can react with nitrite under mildly acid conditions,
simulating those in the human stomach, to form N-nitrosodiethylamine,
which has been shown to be carcinogenic in ten animal species (IARC, 1972).
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Subsequent evaluation: Suppl. 7 (1987) (p. 63: Group 3)
For definition of Groups, see Preamble Evaluation.
- Bis[(diethylamino)thioxomethyl] disulfide
- Bis(diethylthiocarbamoyl) disulfide
- Bis(N,N-diethylthiocarbamoyl) disulfide
- Ekagom TEDS
- Ethyl thiram
- Ethyl thiurad
- Ethyl tuads
- Ethyl Tuex
- Tetraethylthiram disulfide
- Tetraethylthiuram disulfide
- N,N,N',N'-Tetraethylthiuram disulfide
- Tetraethylthiuran disulfide
- Thiuram E
Last updated: 25 March 1998