ICSC 0422 - COUMAPHOS

COUMAPHOS

ICSC: 0422
_{Peer-Review Status: 10.07.1997 Validated}

O-3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate
Phosphorothioic acid O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester
O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate

CAS #: 56-72-4 RTECS #: GN6300000
UN #: 3027
EC #: 015-038-00-3
EINECS #: 200-285-3

Formula: C₁₄H₁₆ClO₅PS
Molecular mass: 362.78

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRST AID / FIRE FIGHTING
FIRE	Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings, use appropriate extinguishing media.
EXPLOSION

EXPOSURE		PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!	IN ALL CASES CONSULT A DOCTOR!
Inhalation	Convulsions. Dizziness. Sweating. Laboured breathing. Nausea. Unconciousness. Pupillary constriction, muscle cramp, excessive salivation. Symptoms may be delayed. See Notes.	Use local exhaust or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Skin	MAY BE ABSORBED! Further see Inhalation.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Eyes		Wear face shield or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal cramps. Diarrhoea. Vomiting. Further see Inhalation.	Do not eat, drink, or smoke during work.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention .

SPILLAGE DISPOSAL	PACKAGING & LABELLING
Evacuate danger area! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	Do not transport with food and feedstuffs. Severe marine pollutant. EC Classification Symbol: T+, N; R: 21-28-50/53; S: (1/2)-28-36/37-45-60-61 UN Classification UN Hazard Class: 6.1 GHS Classification

EMERGENCY RESPONSE	SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT7-I.	Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.

IMPORTANT DATA

Physical State; Appearance
COLOURLESS CRYSTALS WITH CHARACTERISTIC ODOUR.

Physical dangers
No data.

Chemical dangers
Decomposes on heating. This produces toxic fumes including sulfur oxides, phosphorus oxides and hydrogen chloride. Reacts slowly with bases (hydrolysis).

Occupational exposure limits
TLV (inhalable vapor and aerosol): 0.05mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2007).

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.

Effects of short-term exposure
Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated.

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms.

PHYSICAL PROPERTIES

ENVIRONMENTAL DATA

Melting point: 91°C
Density: 1.47 g/cm³
Solubility in water: none
Vapour pressure, Pa at 20°C: 0.000013
Octanol/water partition coefficient as log Pow: 4.13

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to fish, crustacea, birds and mammals. Bioaccumulation of this chemical may occur in fish. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

NOTES

Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Asuntol, Co-ral, Meldane, Muscatox, Perizin, Resitox, Negashunt are trade names.
Card has been partly updated in October 2005.
See section Emergency Response.
Card has been partially updated in July 2007: see Occupational Exposure Limits.

ADDITIONAL INFORMATION

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012

LEGAL NOTICE

Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.

    See Also:
       Toxicological Abbreviations
       Coumaphos (FAO/PL:1968/M/9/1)
       Coumaphos (WHO Pesticide Residues Series 2)
       Coumaphos (WHO Pesticide Residues Series 5)
       Coumaphos (Pesticide residues in food: 1978 evaluations)
       Coumaphos (Pesticide residues in food: 1980 evaluations)
       Coumaphos (Pesticide residues in food: 1983 evaluations)
       Coumaphos (Pesticide residues in food: 1990 evaluations Toxicology)