IPCS INCHEM Home
COUMAPHOSICSC: 0422
April 2013
CAS #: 56-72-4O-3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate
Phosphorothioic acid O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester
O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate
UN #: 3027
EINECS #: 200-285-3

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.        In case of fire in the surroundings, use appropriate extinguishing media.  In case of fire: keep drums, etc., cool by spraying with water. 

 PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! FIRST AID: USE PERSONAL PROTECTION. 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Headache. Sweating. Weakness. Nausea. Vomiting. Pupillary constriction, muscle cramp, excessive salivation. Laboured breathing. Unconsciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . See Notes. 
Eyes Redness.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. NO mouth-to-mouth artificial respiration. Refer immediately for medical attention. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance and protective clothing. Do NOT wash away into sewer. Collect the spilled substance into containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

skull;toxicexcl mark;warnenviro;aqua
DANGER
Fatal if swallowed or if inhaled
Harmful in contact with skin
Very toxic to aquatic life with long lasting effects 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 

STORAGE
Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. 
PACKAGING
Do not transport with food and feedstuffs.
Marine pollutant. 
COUMAPHOS ICSC: 0422
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS CRYSTALS WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including sulfur oxides, phosphorus oxides and hydrogen chloride. 

Formula: C14H16ClO5PS
Molecular mass: 362.78
Melting point: 91°C
Density: 1.47 g/cm³
Solubility in water: none
Vapour pressure at 20°C: negligible
Octanol/water partition coefficient as log Pow: 4.13  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Effects of short-term exposure
Cholinesterase inhibition. The substance may cause effects on nervous system. The effects may be delayed. Medical observation is indicated. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


Occupational exposure limits
TLV: 0.05 mg/m3, ppm, as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued 

ENVIRONMENT
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to fish, crustacea, birds and mammals. Bioaccumulation of this chemical may occur in fish. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Isolate contaminated clothing by sealing in a bag or other container. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T+, N; R: 21-28-50/53; S: (1/2)-28-36/37-45-60-61 

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material.
    See Also:
       Toxicological Abbreviations
       Coumaphos (FAO/PL:1968/M/9/1)
       Coumaphos (WHO Pesticide Residues Series 2)
       Coumaphos (WHO Pesticide Residues Series 5)
       Coumaphos (Pesticide residues in food: 1978 evaluations)
       Coumaphos (Pesticide residues in food: 1980 evaluations)
       Coumaphos (Pesticide residues in food: 1983 evaluations)
       Coumaphos (Pesticide residues in food: 1990 evaluations Toxicology)