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    1976 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    The content of this document is the result of the deliberations of the
    Joint Meeting of the FAO Panel of Experts on Pesticide Residues and
    the Environment and the WHO Expert Group on Pesticide Residues, which
    met in Rome, 22 - 30 November 1976.*

    FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS

    Rome, 1977




            

    * Pesticide Residues in Food: Report of the 1976 Joint Meeting of the
    FAO Panel of Experts on Pesticide Residues and the Environment and the
    WHO Expert Group on Pesticide Residues, WHO Technical Report, Series
    No. 612, 1977; Plant Production and Protection Series No. 8, 1977.

         This document contains summaries of data considered by the Joint
    Meeting of the FAO Panel of Experts on Pesticide Residues and the
    Environment and the WHO Expert Group on Pesticide Residues in arriving
    at recommendations for acceptable daily intakes, tolerances and
    methods of analysis.

         A summary report of the 1976 Joint Meeting* has also been
    published which contains general considerations, including the
    principles adopted for the evaluation and a summary of the results of
    evaluation of a number of pesticide residues.




            

    * Pesticide Residues in Food. Report of the 1976 Joint Meeting of the
    FAO Panel of Experts on Pesticide Residues and the Environment and the
    WHO Expert Group on Pesticide Residues, WHO Technical Report Series
    No. 612, 1977; Plant Production and Protection Series No. 8, 1977.

    M-84

    ISBN 92-5-100442-0

    (C) FAO and WHO 1977

    CONTENTS

    List of attendees

    Introduction

    The Monographs

    Acephate

    Bioresmethrin*

    Captafol*

    Carbaryl*

    Carbendazim*

    Carbofuran (text is not available)

    Carbophenothion*

    Cartap

    Chlormequat*

    Dialifos

    Diphenylamine*

    Diquat*

    Dodine*

    Edifenphos

    Fenitrothion*

    Maleic hydrazide

    Methamidophos

    Methomyl*

    Paraquat*

    Phosalone*

    Phosmet

    Pirimicarb

    Pirimiphos-methyl*

    Thiometon*

    ANNEX 1 - Acceptable daily intakes, residue limits and guideline
    levels recommended at the 1976 Meeting



            

    *  Addendum

    

    LIST OF ATTENDEES

    Members of the FAO Panel of Experts on Pesticide Residues and the
    Environment:

         Dr A.F.H. Besemer, Head, Pesticides Division, Plant Protection
         Service, Ministry of Agriculture, Wageningen, Netherlands

         Professor G. Bressau, Head, Pesticides Unit, Division of Food
         Chemistry, Federal Health Office, Berlin (West)

         Mr F. Bro-Rasmusen, National Food Institute, Division of
         Pesticides and Contaminants, Soborg, Copenhagen, Denmark
         (Rapporteur)


         Mr J.G. Cummings, Chief, Chemistry Branch, Registration Division,
         Office of Pesticide Programs, Environmental Protection Agency,
         Washington, DC, USA

         Mr J.T. Snelson, Pesticides Coordinator, Department of Primary
         Industry, Canberra, Australia (Chairman)

         Dr E.M. Thain, Deputy Directory Tropical Products Institute,
         London, England

    Members of the WHO Expert Group on Pesticide Residues:

         Dr V. Benes, Chief, Toxicology Department, Institute of Hygiene
         and Epidemiology, Prague, Czechoslovakia (Rapporteur)

         Mr D.J. Clegg, Pesticide Section, Toxicological Evaluation
         Division, Health Protection Branch, Department of National Health
         and Welfare, Ottawa, Canada (Vice-Chairman)

         Professor I. Nir, Department of Clinical Pharmacology, Ministry
         of Health, Jerusalem, Israel

         Professor F.K. Ohnesorge, Pharmacological and Technological
         Institute, Düsseldorf, Federal Republic of Germany

         Professor C. Schlatter, Institute of Toxicology, Federal
         Polytechnic, and University of Zürich, Schwerzenbach, Zürich,
         Switzerland

         Dr M. van Logten, Laboratory for General Toxicology, National
         Institute of Public Health, Bilthoven, Netherlands

    Observer invited by FAO:

         Dr A.J. Pieters, Chairman, Codex Committee on Pesticide Residues,
         Directorate of Public Health, Foodstuffs Division, Leidschendam,
         Netherlands

    Secretariat:

         Dr C. Agthe, Chief, Food Additives, WHO, Geneva, Switzerland

         Dr R. Baron, Health Effects Research Laboratory, Environmental
         Research Center, United States Environmental Protection Agency,
         Research Triangle Park, USA (Temporary Adviser)

         Dr L.G. Ladomery, Joint FAO/WHO Food Standards Programme, Rome,
         Italy

         Dr R. Leski, Chemical Residue and Pollution Section, Joint
         FAO/IAEA Division of Atomic Energy in Agriculture, International
         Atomic Energy Agency, Vienna, Austria

         Mr A.F. Machin, Senior Research Officer, Central Veterinary
         Laboratory, Ministry of Agriculture, Weybridge, England
         (Consultant)

         Dr E. Middleton, Food Directorate, Health Protection Branch,
         Department of National Health and Welfare, Ottawa (Temporary
         Adviser)

         Dr Orville E. Paynter, Chief, Toxicology Branch, Registration
         Division, Office of Pesticide Programs, US Environmental
         Protection Agency, Washington, DC, USA (Temporary Adviser)

         Dr E.E. Turtle, Pesticides Specialist, Plant Protection Service,
         FAO, Rome, Italy (Joint Secretary)

         Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva,
         Switzerland (Joint Secretary)

    INTRODUCTION

         A Joint Meeting of the FAO Panel of Experts on Pesticide Residues
    and the Environment and the WHO Expert Group on Pesticide Residues was
    held in Rome from 22 to 30 November 1976. The report on the session
    which is entitled "Report of the 1976 Joint Meeting of the FAO Panel
    of Experts on Pesticide Residues and the Environment and the WHO
    Expert Group on Pesticide Residues" provides information on the
    general principles followed and considerations of the meeting. It also
    contains a summary of the evaluations made on residues in foods of the
    various pesticides considered at the session. The present document
    contains recommendations for acceptable daily intakes, for maximum
    acceptable residue levels and for methods of analysis together with
    summaries of the data considered by the Meeting in making these
    recommendations.

         As much relevant information as possible has been included in the
    monographs. This has been obtained from the published literature
    wherever possible, but other sources of information have also been
    used. Early and complete publications of the results of research in
    this field are very important, particularly of that part which could
    form the basis for estimation of acceptable daily intakes and
    appropriate residue levels. Publication allows the research to be
    scrutinized and criticized by scientists from disciplines not
    necessarily represented at the meeting. Data contained in unpublished
    reports is less satisfactory and, when considered, must be complete
    and nonconfidential and indicate authorship.

         Some of the compounds considered at this meeting have been
    previously evaluated and reported on in earlier publications. If only
    a limited amount of additional information of these compounds has
    become available at this meeting, only this latter information is
    summarized in the pertinent monograph, and reference is made to the
    previously published evaluation, which should also be consulted by the
    reader who wishes to obtain a complete evaluation of the compound.
    Such monograph addenda are indicated by an asterisk in the "Contents",
    p. iii.

         The Annex at the end of this volume of monographs is a
    reproduction of Annex I of the Report of the 1976 Joint Meeting and
    gives a summary of the recommendations concerning acceptable daily
    intakes, residue limits and guideline levels recommended at the 1976
    Meeting.

    NOTE TO THE READER

         Any comments on evaluation for acceptable daily intake should be
    addressed to:

                                  Food Additives Unit
                                  World Health Organization
                                  Geneva, Switzerland

         Any comments on residues in food and their evaluation should be
    addressed to:

                                  Plant Protection Service
                                  Plant Production and Protection Division
                                  Food and Agriculture Organization
                                  Rome, Italy






















    See Also:
       Toxicological Abbreviations