For definition of Groups, see Preamble Evaluation.
Supplement 7: (1987) (p. 390)
Chem. Abstr. Name: 4-(Phenylazo)benzenamine
Evidence for carcinogenicity to animals (sufficient)
para-Aminoazobenzene produced liver tumours in rats following its oral administration and produced epidermal tumours in rats after application to the skin [ref: 1]. In mice, hepatomas were found in 50-100% of males after one or four intraperitoneal injections of para-aminoazobenzene, compared to 3% in controls and in females. In two other strains of mice, 93% and 46% of males had hepatomas at 11 months of age after a single intraperitoneal injection of the compound [ref: 2]. When pregnant and newborn male and female mice were administered high doses of para-aminoazobenzene by subcutaneous injection, there was a borderline increase in the incidences of tumours of the liver and of the haematopoietic and lymphoid tissues in mice treated transplacentally and a statistically significant increase in the incidence of these tumours in neonates [ref: 3].
para-Aminoazobenzene is possibly carcinogenic to humans (Group 2B).
For definition of the italicized terms, see Preamble Evaluation.
Also see previous evaluation: Vol. 8 (1975)
1. IARC Monographs, 8, 53-60, 1975
2. Delclos, K.B., Tarpley, W.G., Miller, E.C. & Miller, J.A. (1984) 4-Aminoazobenzene and N,N-dimethyl-4-aminoazobenzene as equipotent hepatic carcinogens in male C57BL/6xC3H/HeF1 mice and characterization of N-(deoxyguanosin-8-yl)-4-aminoazobenzene as the major persistent hepatic DNA-bound dye in these mice. Cancer Res., 44, 2540-2550
3. Fujii, K. (1983) Induction of tumors in transplacental or neonatal mice administered 3'-methyl-4-dimethylaminoazobenzene or 4-aminoazobenzene. Cancer Lett., 17, 321-325
See Also: Toxicological Abbreviations Aminoazobenzene, para- (IARC Summary & Evaluation, Volume 8, 1975)