For definition of Groups, see Preamble Evaluation.
Supplement 7: (1987) (p. 203)
CAS No.:
A. Evidence for carcinogenicity to humans (sufficient)
Descriptive studies have demonstrated very high mortality from malignant mesothelioma, mainly of the pleura, in three Turkish villages where there was contamination from erionite and where exposure had occurred from birth [ref: 1].
B. Evidence for carcinogenicity to animals (sufficient)
Erionite has been tested in mice by intraperitoneal injection and in rats by inhalation, intrapleural and intraperitoneal administration, producing high incidences of mesotheliomas [ref: 1,2].
C. Other relevant data
Erionite fibres were identified in lung tissue samples in cases of pleural mesothelioma; ferruginous bodies were found in a much higher proportion of inhabitants in contaminated villages in Turkey than in those of two control villages [ref: 1].
No data were available on the genetic and related effects of erionite in humans. It induced unscheduled DNA synthesis in human cells in vitro and transformation and unscheduled DNA synthesis in mouse C3H 10T1/2 cells [ref: 3].
Overall evaluation
Erionite is carcinogenic to humans (Group 1).
For definition of the italicized terms, see Preamble Evaluation.
Also see previous evaluation: Vol. 42 (1987)
References
1. IARC Monographs, 42, 225-239 1987
2. Pott, F. (1987) The fibre as a carcinogenic agent (Ger.). Zbl. Bakt. Hyg. B, 184, 1-23
3. IARC Monographs, Suppl. 6, 291-292, 1987
See Also:
Toxicological Abbreviations
Erionite (IARC Summary & Evaluation, Volume 42, 1987)