International Agency for Research on Cancer (IARC) - Summaries & Evaluations

For definition of Groups, see Preamble Evaluation.

Supplement 7:: (1987) (p. 391)

CAS No.: 126-07-8
Chem. Abstr. Name: 2-S-trans)-7-Chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-(2)-cyclohexene]-3,4'-dione

A. Evidence for carcinogenicity to animals (sufficient)

Griseofulvin induced liver tumours following its oral administration to adult mice [ref: 1-3] or its subcutaneous administration to infant male mice [ref: 1]. When given orally to rats and hamsters, it produced a significant increase in the incidence of thyroid tumours in rats but had no carcinogenic effect in hamsters [ref: 2].

Overall evaluation

Griseofulvin is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 79 (2001)

Also see previous evaluation: Vol. 10 (1976)

References

1. IARC Monographs, 10, 153-161, 1976

2. Rustia, M. & Shubik, P. (1978) Thyroid tumours in rats and hepatomas in mice after griseofulvin treatment. Br. J. Cancer, 38, 237-249

3. Chlumská, A.A. & Janousek, V. (1981) Hepatomas after long-term administration of griseofulvin (Czech.). Cesk. Patol., 17, 83-87

Synonyms

• Amudane
• Biogrisin-FP
• 7-Chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'-methylcyclohex-2'-en-4'-one)
• 7-Chloro-2',4,6-trimethoxy-6'b-methylspiro[benzofuran-2(3H),1'-(2)-cyclohexene]-3,4'-dione
• 7-Chloro-2',4,6-trimethoxy-6'-methyl-(2S-trans)-spiro[benzofuran-2H(3H),1'-(2)-cyclohexene]-
  3,4'-dione
• Curling factor
• Delmofulvina
• Fulcin
• Fulcine
• Fulvicin
• Fulvina
• Fungivin
• Fulvistatin
• Greosin
• Gricin
• Grifulvin
• Grisactin
• Griscofulvin
• Grisefuline
• Griseo
• (+)-Griseofulvin
• Grisetin
• Grisofulvin
• Grisovin
• Grysio
• Guservin
• Lamoryl
• Likuden
• Neo-Fulcin
• NSC 34533
• Poncyl
• Spirofulvin
• Sporostatin

    See Also:
       Toxicological Abbreviations
       Griseofulvin  (IARC Summary & Evaluation, Supplement7, 1987)
       Griseofulvin  (IARC Summary & Evaluation, Volume 10, 1976)
       Griseofulvin  (IARC Summary & Evaluation, Volume 79, 2001)