International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 1 (1972) (p. 135)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Nitrosoethylurea is carcinogenic in all four animal species tested. The main target organs are the kidney, nervous system and lympho-reticular system. Tumours have been induced following different routes of administration, including single oral doses. Prenatal exposure to the substance has been shown to be particularly effective in producing tumours of the nervous system.

5.2 Human carcinogenicity data

The compound can be formed from ethylurea by nitrosation in vivo. No data on direct human exposure are available.

Subsequent evaluations: Vol. 17 (1978); Suppl. 7 (1987) (p. 63: Group 2A)

For definition of Groups, see Preamble Evaluation.

Last updated: 12 March 1998

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       Toxicological Abbreviations