International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 1 (1972) (p. 125)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Nitrosomethylurea (NMU) is carcinogenic in all six animal species
tested. It has a local as well as a systemic carcinogenic effect,
producing tumours at different sites, including the nervous tissue. It
induces tumours following different routes of administration,
including ingestion. It is carcinogenic in single-dose experiments and
following prenatal exposure.
5.2 Human carcinogenicity data
The compound may be formed in vivo from methylurea and nitrite or
other nitrosating agents. No data on direct human exposure are
Subsequent evaluations: Vol. 17 (1978); Suppl. 7 (1987) (p. 66: Group 2A)
For definition of Groups, see Preamble Evaluation.
Last updated: 12 March 1998