International Agency for Research on Cancer (IARC) - Summaries & Evaluations
DIBENZO(a,i)PYRENE
VOL.: 3 (1973) (p. 215)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Subcutaneous injections of dibenzo(a,i)pyrene resulted in the rapid appearance of local
sarcomas in the hamster and the mouse. The smallest single dose which
produced sarcomas in mice was 50 mg. Repeated skin application
in mice was also effective, but dibenzo(a,i)pyrene was less active than
benzo(a)pyrene. It has not been tested by other routes or in other
species.
5.2 Human carcinogenicity data
No case reports or epidemiological studies on the significance of
dibenzo(a,i)pyrene exposure to man are available. However, coal-tar and other
materials which are known to be carcinogenic to man may contain
dibenzo(a,i)pyrene. The substance has also been detected in other environmental
situations. The possible contribution of polycyclic aromatic
hydrocarbons from some environmental sources to the overall
carcinogenic risk to man is discussed in the General Remarks.
Subsequent evaluations: Vol. 32 (1983); Suppl. 7 (1987) (p. 62: Group 2B)
For definition of Groups, see Preamble Evaluation.
Last updated: 16 March 1998