1-Naphthylamine (IARC Summary & Evaluation, Volume 4, 1974)
International Agency for Research on Cancer (IARC) - Summaries & Evaluations
1-NAPHTHYLAMINE
VOL.: 4 (1974) (p. 87)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
No carcinogenic effect of 1-naphthylamine was observed in the hamster
following oral administration. The results obtained after oral and
subcutaneous administration to mice are inconclusive. The experiments
in dogs demonstrate that 1-naphthylamine, if carcinogenic at all, is
less so to the bladder in this species than is the 2-isomer.
5.2 Human carcinogenicity data
Occupational exposure to commercial 1-naphthylamine containing 4-10%
2-naphthylamine is strongly associated with bladder cancer. A number
of case reports from several countries support this association. It is
not possible on present evidence to decide whether 1-naphthylamine
free from the 2-isomer is carcinogenic to man.
Subsequent evaluation:
Suppl. 7 (1987)
Last updated: 16 March 1998
See Also:
Toxicological Abbreviations
Naphthylamine, 1- (IARC Summary & Evaluation, Supplement7, 1987)