International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 4 (1974) (p. 87)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

No carcinogenic effect of 1-naphthylamine was observed in the hamster following oral administration. The results obtained after oral and subcutaneous administration to mice are inconclusive. The experiments in dogs demonstrate that 1-naphthylamine, if carcinogenic at all, is less so to the bladder in this species than is the 2-isomer.

5.2 Human carcinogenicity data

Occupational exposure to commercial 1-naphthylamine containing 4-10% 2-naphthylamine is strongly associated with bladder cancer. A number of case reports from several countries support this association. It is not possible on present evidence to decide whether 1-naphthylamine free from the 2-isomer is carcinogenic to man.

Subsequent evaluation: Suppl. 7 (1987)

Last updated: 16 March 1998

    See Also:
       Toxicological Abbreviations
       Naphthylamine, 1-  (IARC Summary & Evaluation, Supplement7, 1987)