2-Naphthylamine (IARC Summary & Evaluation, Volume 4, 1974)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

2-NAPHTHYLAMINE

VOL.: 4 (1974) (p. 97)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

2-Naphthylamine is carcinogenic in the mouse, hamster, dog and monkey. Given orally it has produced bladder carcinomas in the dog and monkey, and, at high dosage levels, in the hamster. By this route, it has increased the incidence of hepatomas in the mouse; in the rat and rabbit, it has little, if any, carcinogenic effect.

5.2 Human carcinogenicity data

Epidemiological studies have shown that occupational exposure to 2-naphthylamine, either alone or when present as an impurity in other compounds, is strongly associated with the occurrence of bladder cancer. There is no doubt that 2-naphthylamine is a human bladder carcinogen.

Subsequent evaluation: Suppl. 7 (1987)

Last updated: 16 March 1998





























    See Also:
       Toxicological Abbreviations
       Naphthylamine, 2- (IARC Summary & Evaluation, Supplement7, 1987)