Isonicotinic Acid Hydrazide (IARC Summary & Evaluation, Volume 4, 1974)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

ISONICOTINIC ACID HYDRAZIDE (ISONIAZID)

VOL.: 4 (1974) (p. 159)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Isonicotinic acid hydrazide (INH) is carcinogenic in mice after oral, subcutaneous and intraperitoneal administration. The observation of tumours in rats in only one of several oral studies is inconclusive. INH failed to produce tumours in hamsters when given orally.

5.2 Human carcinogenicity data

Available evidence from the first 15 years of human exposure has not suggested that INH is carcinogenic in man in the doses applicable to treatment and prophylaxis of tuberculosis.

Subsequent evaluation: Suppl. 7 (1987)

Last updated: 16 March 1998





























    See Also:
       Toxicological Abbreviations