International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 5 (1974) (p. 39)

CAS No.: 140-57-8

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

AramiteR is carcinogenic in the rat and dog following its oral administration. It produced liver tumours in the rat and carcinomas of the gall bladder and biliary ducts in the dog.

AramiteR was tested in 4 strains of mice by the oral route and produced a significant increase of hepatomas in males of one strain.

No tumours were reported in limited studies involving skin application and subcutaneous injection (single-dose) in mice.

5.2 Human carcinogenicity data

No epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 17 March 1998

    See Also:
       Toxicological Abbreviations
       ARAMITE (JECFA Evaluation)