Norgestrel (IARC Summary & Evaluation, Volume 6, 1974)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

NORGESTREL

VOL.: 6 (1974) (p. 201)

5. Summary of Data Reported and Evaluation

(N.B.: This section should be read in conjunction with the section ' General Conclusions on Hormones'.)

5.1 Animal carcinogenicity data

Norgestrel was tested in one experiment only in mice and rats by the oral route. There was no increase in the incidence of tumours in either species compared with that in controls. Comparable results were obtained when norgestrel was administered in combination with ethinyloestradiol.

5.2 Human carcinogenicity data

No case reports or epidemiological studies on norgestrel alone were available to the Working Group. Epidemiological studies on steroid hormones used in oestrogen-progestin contraceptive preparations have been summarized in the section, "Oestrogens and Progestins in Relation to Human Cancer", in this volume.

Subsequent evaluations: Vol. 21 (1979); Suppl. 7 (1987) (Progestins; Combined oral contraceptives)

Last updated: 18 March 1998





























    See Also:
       Toxicological Abbreviations
       Norgestrel (IARC Summary & Evaluation, Volume 21, 1979)