N-[4-(5-Nitro-2-Furyl)-2-Thiazolyl]Acetamide (IARC Summary & Evaluation, Volume 7, 1974)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

N-[4-(5-NITRO-2-FURYL)-2-THIAZOLYL]ACETAMIDE

VOL.: 7 (1974) (p. 185)

CAS No.: 531-82-8

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA) is carcinogenic in mice, rats (independent of the crystalline form) and hamsters following oral administration, the only route tested. It produced generalized lymphosarcomas and forestomach tumours in mice; mainly mammary carcinomas, salivary gland carcinomas, lung carcinomas and transitional-cell carcinomas of the renal pelvis in rats; and, in hamsters, urinary bladder carcinomas and forestomach tumours. Two dogs given NFTA orally developed gall-bladder adenomas.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Previous evaluation: Vol. 1 (1972)

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms

2-Acetamido-4-(5-nitro-2-furyl)thiadiazole
2-Acetamido-4-(5-nitro-2-furyl)thiazole
2-Acetylamino-4-(5-nitro-2-furyl)thiazole
Furathiazole
Furium
Furothiazole
NFTA
N-[4-(5-Nitro-2-furanyl)-2-thiazolyl]acetamide
N-[4-(5-Nitro-2-furyl)thiazol-2-yl]acetamide

Last updated: 19 March 1998





























    See Also:
       Toxicological Abbreviations
       N-[4-(5-Nitro-2-Furyl)-2-Thiazolyl]Acetamide (IARC Summary & Evaluation, Volume 1, 1972)