International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 8 (1975) (p. 173)

CAS No.: 523-44-4
Chem. Abstr. Name: 4-[(4-Hydroxy-1-naphthalenyl)azo]benzenesulfonic
acid, monosodium salt

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Orange I has been tested by the oral route in mice, rats and dogs, but the studies could not be evaluated due to inadequate reporting. It was also tested by the subcutaneous route in rats, producing injection site tumours.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 69: Group 3)

For definition of Groups, see Preamble Evaluation.


Last updated: 21 March 1998

    See Also:
       Toxicological Abbreviations
       Orange I (WHO Food Additives Series 12)
       ORANGE I (JECFA Evaluation)