International Agency for Research on Cancer (IARC) - Summaries & Evaluations
TRYPAN BLUE
VOL.: 8 (1975) (p. 267)
CAS No.: 72-57-1
Chem. Abstr. Name: 3,3'-{[3,3'-Dimethyl(1,1'-biphenyl)-4,4'-diyl]bis(azo)}bis-
(5-amino-4-hydroxy)-2,7- naphthalenedisulfonic acid, tetra-sodium salt
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Trypan blue is carcinogenic in rats following its subcutaneous or
intraperitoneal injection, producing reticulum-cell sarcomas, mainly
of the liver, as well as fibrosarcomas at the site of injection. Liver
spindle-cell sarcomas were also induced in rats by single subcutaneous
injections. Experiments by the oral route in rats and by
subcutaneous injection in mice could not be evaluated because of the
small number of animals used or because the adequacy of the dose used
could not be assessed.
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 2B)
For definition of Groups, see Preamble Evaluation.
Synonyms
- Amanil sky Blue
- Amidine Blue 4B
- Azidinblau 3B
- Azidine Blue 3B
- Azurro diretto 3B
- Bencidal Blue 3B
- Benzaminblau 3B
- Benzamine Blue
- Benzanil Blue R
- Benzoblau 3B
- Benzo Blue
- Bleu diamine
- Bleu diazole N 3B
- Bleu directe 3B
- Bleue diretto 3B
- Bleu trypane N
- Blue 3B
- Blue EMB
- Brasilamina Blue 3B
- Brasilazina Blue 3B
- Centraline Blue 3B
- Chloramiblau 3B
- Chloramine Blue
- Chlorazol Blue 3B
- Chrome Leather Blue 3B
- C.I. Direct Blue 14
- C.I. Direct Blue 14, tetrasodium salt
- Congoblau 3B
- Congo Blue
- Congo Blue 3B
- Cresotine Blue 3B
- Diaminblau 3B
- Diamine Blue
- p,p'-Diamino-m,m'-dimethyldiphenyl-bisazo-bis(1-amino-8-naphthol-3,6-disulfonic acid), tetrasodium salt
- Dianilblau
- Dianil Blue
- Diaphtamine Blue TH
- Diazine Blue 3B
- Diazol Blue 3B
- 3,3'-[[3,3'-Dimethyl(1,1'-biphenyl)-4,4'-diyl]bis(azo)]bis-(5-amine-4-hydroxy)-2,7-
naphthalenedisulfonic acid, tetrasodium salt
- Diphenyl Blue 3B
- Direct Blau 3B
- Direct Blue 3B
- Directakol Blue 3BL
- Eboliblau 4B
- Hispamin Blue 3BX
- Naphtamine Blue 2B
- Naphtamine Blue 3BX
- Naphthylamine Blue
- Niagara Blue
- Orion Blue 3B
- Paramine Blue 3B
- Parkibleu
- Parkipan
- Pontamine Blue 3BX
- Pyrazol Blue 3B
- Pyrotropblau
- Renolblau 3B
- Sodium ditolyldiazobis-8-amino-1-naphthol-3,6-disulfonate
- Tetrasodium-2,2'-[(3,3'-dimethyl-4,4'-biphenylylene)bis(azo)]-bis(5-amino-4-hydroxy-3,6-
naphthalenedisulfonate)
- Trianol direct Blue 3B
- Triazolblau 3BX
- Tripan Blue
- Trypanblau
- Trypan Blue BPC
- Trypan Blue sodium salt
- Trypane Blue
Last updated: 21 March 1998