International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 8 (1975) (p. 267)

CAS No.: 72-57-1
Chem. Abstr. Name: 3,3'-{[3,3'-Dimethyl(1,1'-biphenyl)-4,4'-diyl]bis(azo)}bis-
(5-amino-4-hydroxy)-2,7- naphthalenedisulfonic acid, tetra-sodium salt

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Trypan blue is carcinogenic in rats following its subcutaneous or intraperitoneal injection, producing reticulum-cell sarcomas, mainly of the liver, as well as fibrosarcomas at the site of injection. Liver spindle-cell sarcomas were also induced in rats by single subcutaneous injections. Experiments by the oral route in rats and by subcutaneous injection in mice could not be evaluated because of the small number of animals used or because the adequacy of the dose used could not be assessed.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 2B)

For definition of Groups, see Preamble Evaluation.


Last updated: 21 March 1998

    See Also:
       Toxicological Abbreviations