International Agency for Research on Cancer (IARC) - Summaries & Evaluations
MANNOMUSTINE (DIHYDROCHLORIDE)
VOL.: 9 (1975) (p. 157)
CAS No.: 576-68-1
Chem. Abstr. Name: 1,6-Bis(2-chloroethylamino)-1,6-dideoxy-D-mannitol
CAS No.: 551-74-6
Chem. Abstr. Name: 1,6-Bis(2-chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Mannomustine administered as the dihydrochloride is carcinogenic in
mice following its intraperitoneal injection, producing an increased
incidence of leukaemia and a dose-related increase in the incidence of
lung tumours.
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation: Suppl. 7 (1987) (p. 65: Group 3)
For definition of Groups, see Preamble Evaluation.
Synonyms for Mannomustine (free base)
- 1,6-Bis(chloroethylamino)-l,6-bis-deoxy-D-mannitol
- 1,6-Bis(chloroethylamino)-1,6-bis-deoxy-D-mannite
- 1,6-Bis[(b-chloroethyl)amino]-1,6-dideoxy-D-mannite
- Mannitol mustard
- Mannitol nitrogen mustard
Synonyms for Mannomustine (dihydrochloride)
- BCM
- 1,6-Bis(chloroethylamino)-1,6-dideoxy-D-mannite
- 1,6-Bis(chloroethylamino)-1,6-dideoxy-D-mannite dihydrochloride
- 1,6-Bis(b-chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride
- Degranol
- Degranol Chinoin
- 1,6-Di(2-chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride
- 1,6-Dideoxy-1,6-di(2-chloroethylamino)-D-mannitol dihydrochloride
- Dimesymannitol
- Mannitol mustard
- Mannitol nitrogen mustard
- Mannogranol
- Mannomustine
- Mannomustine hydrochloride
- NSC 9698
Last updated: 21 March 1998