International Agency for Research on Cancer (IARC) - Summaries & Evaluations
MELPHALAN, MEDPHALAN AND MERPHALAN
VOL.: 9 (1975) (p. 167)
Melphalan
CAS No.: 148-82-3
Chem. Abstr. Name: 4-[Bis(2-chloroethyl)amino]-L-phenylalanine
Medphalan
CAS No.: 13045-94-8
Chem. Abstr. Name: 4-[Bis(2-chloroethyl)amino]-D-phenylalanine
Merphalan
CAS No.: 531-76-0
Chem. Abstr. Name: 4-[Bis(2-chloroethyl)amino]-DL-phenylalanine
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Melphalan is carcinogenic in mice and rats following its
intraperitoneal injection, producing lymphosarcomas and a dose-related
increase in lung tumours in mice and peritoneal sarcomas in rats.
Merphalan (a mixture of medphalan and melphalan) produced an increased
incidence of mammary fibroadenomas in rats following its
intraperitoneal injection in single doses.
5.2 Human carcinogenicity data
The available care reports suggest that the incidence of acute
leukaemia is increased in myeloma patients treated with melphalan.
Subsequent evaluation: Suppl. 7 (1987) (Melphalan - Group 1);
Suppl. 7 (p. 65) (Medphalan - Group 3, Merphalan - Group 2B)
For definition of Groups, see Preamble Evaluation.
Synonyms for Melphalan
- Alkeran
- L-3-{para-[Bis(2-chloroethyl)amino]phenyl}alanine
- CB 3025
- para-Di(2-chloroethyl)amino-L-phenylalanine
- para-Di(2-chloroethyl)aminophenylalanine
- Melfalan
- NSC-88-6
- Phenylalanine mustard
- L-Phenylalanine mustard
- Phenylalanine nitrogen mustard
- Sarcolysin
- L-Sarcolysin
- Sarcolysine
- L-Sarcolysine
- L-Sarkolysin
- SK-15673
Synonyms for Medphalan
- (+)-3-{para-[Bis(2-chloroethyl)amino]phenyl}alanine
- D-3-{para-[Bis-(2-chloroethyl)amino]phenyl}alanine
- CB-3026
- para-Di(2-chloroethyl)amino-D-phenylalanine
- Medfalan
- NSC-35051
- D-Phenylalanine mustard
- D-Sarcolysine
Synonyms for Merphalan
- 3-{para-[Bis(2-chloroethyl)amino]phenyl}alanine
- DL-3-{para-[Bis-(2-chloroethyl)amino]phenyl}alanine
- CE-3307
- para-Di(2-chloroethyl)-DL-phenylalanine
- Merfalan
- NSC-14210
- Phenylalanine mustard
- DL-Phenylalanine mustard
- Sarcoclorin
- Sarcolysin
- DL-Sarcolysin
- Sarcolysine
- DL-Sarcolysine
Last updated: 21 March 1998