International Agency for Research on Cancer (IARC) - Summaries & Evaluations
NITROGEN MUSTARD (HYDROCHLORIDE)
VOL.: 9 (1975) (p. 193)
CAS No.: 51-75-2
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanimine
CAS No.: 55-86-7
Chem. Abstr. Name: 2-Chloro-N-(2-chloroethyl)-N-methylethanimine hydrochloride
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Nitrogen mustard, administered mainly as the hydrochloride, is
carcinogenic in mice and rats. Following its subcutaneous,
intraperitoneal or intravenous injection, it produced an increased
incidence of lung tumours and thymic lymphomas in mice; it produced a
variety of malignant tumours in rats following its intravenous
injection.
5.2 Human carcinogenicity data
No case reports or epidemiological studies referring to exposures to
nitrogen mustard alone were available to the Working Group.
Subsequent evaluation: Suppl. 7 (1987) (Nitrogen mustard)
Synonyms for Nitrogen mustard
- N,N-Bis(2-chloroethyl)-N-methylamine
- N,N-Bis(2-chloroethyl)methylamine
- Bis(2-chloroethyl)methylamine
- Bis(b-chloroethyl)methylamine
- Caryolysin
- Chloramine
- Chlormethine
- Cloramin
- b,b'-Dichlorodiethyl-N-methylamine
- Di(2-chloroethyl)methylamine
- b,b'-Dichloro-N-methyldiethylamine
- Embichin
- HN2
- MBA
- Mechlorethamine
- N-Methyl-bis(2-chloroethyl)amine
- N-Methyl-bis(b-chloroethyl)amine
- Methylbis(b-chloroethyl)amine
- Methylbis(chloroethylamine)
- N-Methyl-2,2'-dichlorodiethylamine
- Methyldi(2-chloroethyl)amine
- Mustargen
- Mustine
- Mutagen
- Nitrogen mustard
Synonyms for Nitrogen mustard hydrochloride
- Azotoperite
- N,N-Bis(2-chloroethyl)methylamine hydrochloride
- Bis(2-chloroethyl)methylamine hydrochloride
- Caryolysine
- Chloramin
- Chloramine
- Chlorethamine
- Chlorethazine
- Dichloren
- b1-Dichlorodiethyl-N-methylamine hydrochloride
- Di(2-chloroethyl)methylamine hydrochloride
- Di(chloroethyl)methylamine chloride
- b,b'-Dichloro-N-methyl-diethylamine hydrochloride
- Dimitan
- Embichin
- Embikhine
- Erasol
- HN2
- HN2 hydrochloride
- MBA hydrochloride
- Mebichloramine
- Mechlorethamine
- Mechlorethamine hydrochloride
- Metagen
- N-Methylbis(2-chloroethyl)amine hydrochloride
- Methylbis(2-chloroethyl)amine hydrochloride
- N-Methylbis(b-chloroethyl)amine hydrochloride
- Methylbis(b-chloroethyl)amine hydrochloride
- N-Methyl-2,2'-dichlorodiethylamin hydrochloride
- Methyldi(2-chloroethyl)amine hydrochloride
- Methyldi(b-chloroethyl)amine hydrochloride
- Mitoxine
- Mustargen
- Mustargen hydrochloride
- Mustine
- Mustine Hydrochlor
- Mustine hydrochloride
- Nitrogen mustard
- Nitrogranulogen
- N-Lost
- NSC-762 hydrochloride
Last updated: 21 March 1998