International Agency for Research on Cancer (IARC) - Summaries & Evaluations
OESTRADIOL MUSTARD
VOL.: 9 (1975) (p. 217)
CAS No.: 22966-79-6
Chem. Abstr. Name: Estra-1,3,5(10)-triene-3,17b-diol,bis({para-[bis-(2-chloroethyl)-
amino]phenyl}acetate)
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Oestradiol mustard is carcinogenic in mice following its
intraperitoneal injection, the only species and route tested,
producing a dose-related increase in the incidence of lung tumours.
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation: Suppl. 7 (p. 68: Group 3)
For definition of Groups, see Preamble Evaluation.
Synonyms
- Bis{(4-[bis(2-chloroethyl)amino]benzene}acetate)estra-1,3,5(10)-triene-3,17-diol(17b)
- Bis({4-[bis(2-chloroethyl)amino]benzene}acetate]oestra-1,3,5(10)-triene-3,17-diol(17b)
- Bis({para[bis(2-chloroethyl)amino]phenyl}acetate)estradiol
- Bis{(para[bis(2-chloroethyl)amino]phenyl}acetate)estra-1,3,5(10)-triene-3,17b-diol
- Bis{[para[bis(2-chloroethyl)amino]phenyl}acetate)oestra-1,3,5(10)-triene-3,17b-diol
- Bis{[para[bis(2-chloroethyl)-phenyl}acetate)oestradiol
- NSC 112259
Last updated: 21 March 1998