Actinomycins (IARC Summary & Evaluation, Volume 10, 1976)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

ACTINOMYCINS

VOL.: 10 (1976) (p. 29)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Actinomycin D is carcinogenic in rats following its intraperitoneal injection: it produced malignant mesenchymal tumours in the peritoneal cavity. Actinomycins L and S produced sarcomas at the site of their subcutaneous injection in mice. Actinomycin C produced no carcinogenic effect in rats following its intravenous injection.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987)

Last updated: 22 March 1998





























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