International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 10 (1976) (p. 99)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

There are no adequate feeding studies with pure cholesterol available to evaluate its carcinogenicity. Experiments involving subcutaneous injection of cholesterol in various vehicles cannot be evaluated because of variations in parameters unrelated to the dose of cholesterol administered. Implantation experiments using cholesterol are difficult to interpret, because the effects of the physical factors must be taken into consideration.

On the basis of the experimental evidence available no assessment of the carcinogenicity of cholesterol is possible.

5.2 Human carcinogenicity data

No data are available to assess the carcinogenicity of exogenous cholesterol in man. Studies of cancer in relation to dietary fat, serum cholesterol levels and the degradation of biliary steroids are not directly relevant to this question.

Subsequent evaluations: Vol 31 (1983); Suppl. 7 (1987)

Last updated: 22 March 1998

    See Also:
       Toxicological Abbreviations
       Cholesterol  (IARC Summary & Evaluation, Supplement7, 1987)
       Cholesterol (IARC Summary & Evaluation, Volume 31, 1983)