International Agency for Research on Cancer (IARC) - Summaries & Evaluations
HYDROXYSENKIRKINE
VOL.: 10 (1976) (p. 265)
CAS No.: 26782-43-4
Chem. Abstr. Name: 8,12,18-Trihydroxy-4-methyl-11,16-dioxosenecionanium
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Hydroxysenkirkine was tested only by the intraperitoneal route in five
male rats, producing tumours of the brain in one animal. The available
information is insufficient to evaluate the carcinogenicity of this
compound (see also section "General Information and Conclusions on
Pyrrolizidine Alkaloids", in this volume).
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 3)
For definition of Groups, see Preamble Evaluation.
Synonyms
- Stereoisomer of 4-ethylidene-7-hydroxy-7a-(hydroxymethyl)-6,14-
dimethyl-
2,9-dioxa-1,14-azabicyclo (9.5.1) heptadec-11-ene-3,8,17-trione
- trans-15-Ethylidene-12b-hydroxy-12a-hydroxymethyl-4,13b-
dimethyl-
8-oxo-4,8-secosenec-l-enine
Last updated: 22 March 1998