International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 10 (1976) (p. 265)

CAS No.: 26782-43-4
Chem. Abstr. Name: 8,12,18-Trihydroxy-4-methyl-11,16-dioxosenecionanium

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Hydroxysenkirkine was tested only by the intraperitoneal route in five male rats, producing tumours of the brain in one animal. The available information is insufficient to evaluate the carcinogenicity of this compound (see also section "General Information and Conclusions on Pyrrolizidine Alkaloids", in this volume).

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 3)

For definition of Groups, see Preamble Evaluation.


Last updated: 22 March 1998

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