International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 10 (1976) (p. 269)

CAS No.: 15503-86-3
Chem. Abstr. Name: 12,18-Dihydroxysenecionan-11,16-dione-4-oxide

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Isatidine is carcinogenic in rats as shown by a limited study in which it produced liver tumours following its oral administration (see also section "General Information and Conclusions on Pyrrolizidine Alkaloids", in this volume).

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 65: Group 3)

For definition of Groups, see Preamble Evaluation.


Last updated: 22 March 1998

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