International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 10 (1976) (p. 199)

CAS No.: 10048-32-5
Chem. Abstr. Name: (S)-5,6-Dihydro-6-methyl-2H-pyran-2-one

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Parasorbic acid administered by subcutaneous injection to rats produced local sarcomas. Feeding experiments in rats where parasorbic acid was given in combination with sorbic acid cannot be evaluated because of the relatively low dose of parasorbic acid administered and the lack of contemporary control groups. A further oral study in rats was considered inadequate due to the small number of surviving animals.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 69: Group 3)

For definition of Groups, see Preamble Evaluation.


Last updated: 22 March 1998

    See Also:
       Toxicological Abbreviations