International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 10 (1976) (p. 303)

CAS No.: 480-54-6
Chem. Abstr. Name: 12,18-Dihydroxysenecionan-11,16-dione

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Retrorsine is carcinogenic in rats following its oral administration; it produced a variety of tumours. No other species or routes of administration were tested (see also the section "General Information and Conclusions on Pyrrolizidine Alkaloids", in this volume).

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 71: Group 3)

For definition of Groups, see Preamble Evaluation.


Last updated: 22 March 1998

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