International Agency for Research on Cancer (IARC) - Summaries & Evaluations
SAFROLE, ISOSAFROLE, AND DIHYDROSAFROLE
VOL.: 10 (1976) (p. 231)
Safrole
CAS No.: 94-59-7
Chem. Abstr. Name: 5-(2-Propenyl)-1,3-benzodioxole
Isosafrole
CAS No.: 120-58-1
Chem. Abstr. Name: 5- (1-Propenyl) -1,3-benzodioxole
Dihydrosafrole
CAS No.: 94-58-6
Chem. Abstr. Name: 5-Propyl-1,3-benzodioxole
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
Safrole and isosafrole are carcinogenic in mice and rats; they produce
liver tumours following their oral administration. Safrole also
produced liver and lung tumours in male infant mice following its
subcutaneous injection. Dihydrosafrole given orally is carcinogenic in
rats, in which it produces tumours of the oesophagus, and in mice, in
which it produces liver tumours in males and an increased incidence of
lung tumours in both males and females.
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Previous evaluation: Vol. 1 (1972)
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Dihydrosafrole - Group 2B; p. 65: Isosafrole - Group 3; p. 71: Safrole - Group 2B)
For definition of Groups, see Preamble Evaluation.
Synonyms for Safrole
- 5-Allyl-1,3-benzodioxole
- Allylcatechol methylene ether
- Allyldioxybenzene methylene ether
- 1-Allyl-3,4-methylenedioxybenzene
- 4-Allyl-1,2-(methylenedioxy)benzene
- 4-Allyl-1,2-methylenedioxybenzene
- Allylpyrocatechin methylene ether
- m-Allylpyrocatechin methylene ether
- 4-Allylpyrocatechol, formaldehyde acetal
- Allylpyrocatechol methylene ether
- 3,4-Methylenedioxyallylbenzene
- Rhyuno oil
- Safrol
- Safrole MF
- Shikimole
- Shikomol
Synonyms for Isosafrole
- 1,2-(Methylenedioxy)-4-propenylbenzene
- 3,4-Methylenedioxy-1-propenylbenzene
- 3,4-(Methylenedioxy)propenylbenzene
- 1,2-Methylenedioxy-4-propenylbenzene
- 1,2-(Methylenedioxy)-4-propenylbenzene
- 5-(Propen-l-yl)-1,3-benzodioxole
- 4-Propenyl-1,2-methylenedioxybenzene
Synonyms for Dihydrosafrole
- Dihydroisosafrole
- 1,2-(Methylenedioxy)-4-propylbenzene
- 3,4-Methylenedioxypropylbenzene
- 4-Propyl-1,2-(methylenedioxy)benzene
Last updated: 22 March 1998