International Agency for Research on Cancer (IARC) - Summaries & Evaluations
PROPHAM
VOL.: 12 (1976) (p. 189)
CAS No.: 122-42-9
Chem. Abstr. Name: Phenylcarbamic acid, 1-methylethyl ester
5. Summary of Data Reported and Evaluation
5.1 Animal carcinogenicity data
In one study in which propham was administered orally to two strains
of mice, no evidence of carcinogenicity was observed. Other studies in
mice, rats and hamsters by oral administration, in mice and rats by
subcutaneous injection and in mice by intraperitoneal or intrapleural
injection also showed no carcinogenicity, but they were inadequate
either in terms of the number of surviving animals, the total dose or
the extent of pathology carried out. Orally administered propham acted
as an initiator in two-stage carcinogenesis studies in mice.
5.2 Human carcinogenicity data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation: Suppl. 7 (1987) (p. 70: Group 3)
For definition of Groups, see Preamble Evaluation.
Synonyms
- Ban-Hoe
- Beet-Kleen
- Carbanilic acid isopropyl ester
- Chem-Hoe
- IFC
- IFK
- INPC
- IPC
- Iso. PPC.
- Isopropyl carbanilate
- Isopropyl carbanilic acid ester
- Isopropyl phenylcarbamate
- Isopropyl N-phenylcarbamate
- 0-Isopropyl N-phenyl carbamate
- N-Phenylcarbamic acid isopropyl ester
- N-Phenyl isopropyl carbamate
- Triherbide-IPC
- Tuberite
- Y 2
Last updated: 25 March 1998