International Agency for Research on Cancer (IARC) - Summaries & Evaluations
HYCANTHONE and HYCANTHONE MESYLATE
VOL.: 13 (1977) (p. 91)
Hycanthone
CAS No.: 3105-97-3
Chem. Abstr. Name: 1-{[2-(Diethylamino)ethyl]amino}-4-
(hydroxymethyl)-9H-thioxanthen-
9-one
Hycanthone mesylate
CAS No.: 23255-93-8
Chem. Abstr. Name: 1-{[2-(Diethylamino)ethyl]amino}-4-(hydroxymethyl)-9H-thioxanthen-
9-one, monomethanesulfonate (salt)
5. Summary of Data Reported and Evaluation
5.1 Animal data
Hycanthone mesylate is carcinogenic in mice previously infected with
Schistosoma mansoni: a significant increase in the incidence of
hepatocellular carcinomas was observed in these mice following
repeated intramuscular injections of this compound. The limited data
available are not sufficient to evaluate whether hycanthone mesylate
is carcinogenic in non-infected animals.
5.2 Human data
No case reports or epidemiological studies were available to the
Working Group.
Subsequent evaluation of Hycanthone mesylate: Suppl. 7 (1987) (p. 64: Group 3)
For definition of Groups, see Preamble Evaluation.
Synonyms for Hycanthone
- 1-{2-(Diethylamino)ethyl]amino}-4-(hydroxymethyl)thioxanthen-9-one
- Lucanthone metabolite
- Win 24933
Synonyms for Hycanthone mesylate
- l-{[2-(Diethylamino)ethyl]amino}-4-(hydroxymethyl)thioxanthen-9-one,
monomethanesulfonate (salt)
- Etrenol
- Hycanthone methanesulfonate
- Hycanthone monomethanesulfonate
Last updated: 25 March 1998