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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

8-HYDROXYQUINOLINE

VOL.: 13 (1977) (p. 101)

CAS No.: 148-24-3
Chem. Abstr. Name: 8-Quinolinol

5. Summary of Data Reported and Evaluation

5.1 Animal data

8-Hydroxyquinoline has been tested in mice and rats by oral, subcutaneous and intravaginal administration and in mice by skin application and bladder implantation. Most of these experiments were of limited value, for the reasons mentioned in the text. Within these limitations, the studies in mice and rats by oral administration and subcutaneous injection or in mice by skin application gave positive or negative results of borderline significance.

Positive results were obtained in bladder implantation experiments when 8-hydroxyquinoline was incorporated in cholesterol pellets but were negative when paraffin wax pellets were employed (see also introduction, in this volume). Its application intravaginally in different vehicles to mice and rats did not significantly increase the incidence of tumours when compared with that in appropriate controls.

No evaluation of the carcinogenicity of 8-hydroxyquinoline can be made on the basis of the available data (however, see also the results obtained in mutagenicity studies).

N.B. - Data on the copper chelate of 8-hydroxyquinoline were discussed, but because its chemical properties and uses are different from those of 8-hydroxyquinoline it will be considered by a further Working Group.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms

Last updated: 25 March 1998 






























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       Toxicological Abbreviations