International Agency for Research on Cancer (IARC) - Summaries & Evaluations
PHENOBARBITAL and PHENOBARBITAL SODIUM
VOL.: 13 (1977) (p. 157)
Phenobarbital:
CAS No.: 50-06-6
Chem. Abstr. Name: 5-Ethyl-5-phenyl-2,4,6-(1H,3H,5H)pyrimidinetrione
Phenobarbital sodium:
CAS No.: 57-30-7
Chem. Abstr. Name: 5-Ethyl-5-phenyl-2,4,6-(1H,3H,5H)pyrimidinetrione,
monosodium salt
5. Summary of Data Reported and Evaluation
5.1 Animal data
Phenobarbital sodium is carcinogenic in mice and rats after its oral
administration for lifetime. In mice, it produced benign and malignant
liver-cell tumours; in rats, benign liver-cell tumours were observed
very late in life.
5.2 Human data
A possible relationship between anticonvulsant therapy in which
phenobarbital was known to be included and the occurrence of cancer in
man has been investigated in one large epidemiological study and
reported in several case studies. In most instances, phenobarbital was
given in conjunction with other drugs, in particular phenytoin. The
available evidence is insufficient to allow an evaluation of the
carcinogenicity of phenobarbital to be made (see also monograph on
phenytoin).
Subsequent evaluations: Suppl. 7 (1987); Vol. 79 (2001)
Synonyms for Phenobarbital
- Adonal
- Aephenal
- Agrypnal
- Amylofene
- Aphenylbarbit
- Aphenyletten
- Austrominal
- Barbapil
- Barbellen
- Barbellon
- Barbenyl
- Barbilettae
- Barbinal
- Barbiphen
- Barbiphenyl
- Barbipil
- Barbita
- Barbivis
- Barbonal
- Barbophen
- Bardorm
- Bartol
- Bialminal
- Blu-phen
- Cabronal
- Calmetten
- Calminal
- Cardenal
- Cemalonal
- Codibarbital
- Coronaletta
- Damoral
- Dezibarbitur
- Dormina
- Dormiral
- Doscalun
- Duneryl
- Ensobarb
- Ensodorm
- Epanal
- Epidorm
- Epilol
- Episedal
- Epsylone
- Eskabarb
- 5-Ethyl-5-phenylbarbituric acid
- Etilfen
- Euneryl
- Fenbital
- Fenemal
- Fenobarbital
- Fenosed
- Fenylettae
- Gardenal
- Gardepanyl
- Glysoletten
- Haplopan
- Haplos
- Helional
- Hennoletten
- Hypnaletten
- Hypnogen
- Hypnolone
- Hypno-Tablinetten
- Hypnotal
- Hysteps
- Lefebar
- Leonal
- Lephebar
- Lepinal
- Linasen
- Liquital
- Lixophen
- Lubergal
- Lubrokol
- Lumen
- Lumesettes
- Lumesyn
- Luminal
- Lumofridetten
- Luphenil
- Luramin
- Molinal
- Neurobarb
- Nirvonal
- Noptil
- Nova-Pheno
- Numol
- Nunol
- Parkotal
- PEBA
- Pharmetten
- Phenaemal
- Phen-Bar
- Phenemal
- Phenobal
- Phenobarbitone
- Phenobarbituric acid
- Phenylbarbital
- Phenobarbyl
- Phenoluric
- Phenonyl
- Phenoturic
- Phenyletten
- Phenylethylbarbiturate
- Phenylethylbarbituric acid
- 5-Phenyl-5-ethylbarbituric acid
- Phenylethylmalonylurea
- Phenyral
- Phob
- Polcominal
- Promptonal
- Sedabar
- Seda-Tablinen
- Sedicat
- Sedizorin
- Sedlyn
- Sedofen
- Sedonal
- Sedonettes
- Sevenal
- Sombutol
- Somnolens
- Somnoletten
- Somnosan
- Somonal
- Spasepilin
- Starifen
- Starilettae
- Stental Extentabs
- Teolaxin
- Thenobarbital
- Triabarb
- Tridezibarbitur
- Triphenatol
- Versomnal
- Zadoletten
- Zadonal
Synonyms for Phenobarbital sodium
- 5-Ethyl-5-phenylbarbituric acid sodium
- 5-Ethyl-5-phenylbarbituric acid sodium salt
- Gardenal sodium
- Luminal sodium
- PBS
- Phenemalum
- Phenobal sodium
- Phenobarbital
- Phenobarbital elixir
- Phenobarbital-sodium
- Phenobarbitone sodium
- Phenobarbitone sodium salt
- Phenylethylbarbituric acid, sodium salt
- Sodium 5-ethyl-5-phenylbarbiturate
- Sodium luminal
- Sodium phenobarbital
- Sodium phenobarbitone
- Sodium phenylethylbarbiturate
- Soluble phenobarbital
- Soluble phenobarbitone
Last updated: 25 March 1998