International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 13 (1977) (p. 233)

CAS No.: 58-14-0
Chem. Abstr. Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine

5. Summary of Data Reported and Evaluation

5.1 Animal data

In the only study available, pyrimethamine produced a significant increase in the number of lung tumours per mouse when it was given intraperitoneally at high doses. This limited evidence of carcinogenicity awaits confirmation.

N.B. - The Working Group was also aware of ongoing carcinogenicity tests in mice and rats (IARC, 1976).

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 71: Group 3)

For definition of Groups, see Preamble Evaluation.


Last updated: 25 March 1998

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       Toxicological Abbreviations