International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 13 (1977) (p. 233)
CAS No.: 58-14-0
Chem. Abstr. Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
5. Summary of Data Reported and Evaluation
5.1 Animal data
In the only study available, pyrimethamine produced a significant
increase in the number of lung tumours per mouse when it was given
intraperitoneally at high doses. This limited evidence of
carcinogenicity awaits confirmation.
N.B. - The Working Group was also aware of ongoing carcinogenicity tests in mice and rats (IARC, 1976).
5.2 Human data
No case reports or epidemiological studies were available to the
Subsequent evaluation: Suppl. 7 (1987) (p. 71: Group 3)
For definition of Groups, see Preamble Evaluation.
- BW 50-63
- NSC 3061
- 4753 R.P.
Last updated: 25 March 1998