Hexamethylphosphoramide (IARC Summary & Evaluation, Volume 15, 1977)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

HEXAMETHYLPHOSPHORAMIDE

VOL.: 15 (1977) (p. 211)

CAS No.: 680-31-9
Chem. Abstr. Name: Hexamethylphosphoric triamide

5. Summary of Data Reported and Evaluation

5.1 Animal data

Hexamethylphosphoramide is carcinogenic in rats, the only species tested, following its administration by inhalation; in this study, which was reported as a preliminary note, it produced squamous-cell carcinomas of the nasal cavity. It has also been inadequately tested in rats by oral administration.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Vol. 71 (1999)

For definition of Groups, see Preamble Evaluation.

Synonyms

ENT 50,882
Hempa
Hexametapol
Hexamethylphosphamide
Hexamethylphosphoric acid triamide
N,N,N,N,N,N-Hexamethylphosphoric triamide
Hexamethylphosphorotriamide
Hexamethylphosphotriamide
HMPA
HMPT
HPT
Phosphoric tris(dimethylamide)
Phosphoryl hexamethyltriamide
Tris(dimethylamino)phosphine oxide
Tris (dimethylamino)phosphorus oxide

Last updated: 13 April 1999





























    See Also:
       Toxicological Abbreviations
       Hexamethylphosphoramide  (IARC Summary & Evaluation, Volume 71, 1999)