N-Nitrosodiethanolamine (IARC Summary & Evaluation, Volume 17, 1978)

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

N-NITROSODIETHANOLAMINE

VOL.: 17 (1978) (p. 77)

CAS No.: 1116-54-7
Chem. Abstr. Name: 2,2'-(Nitrosoimino)bis-ethanol

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosodiethanolamine is carcinogenic in rats after its oral administration and in hamsters after its subcutaneous injection. It produces hepatocellular carcinomas and renal adenomas in rats, and adenocarcinomas of the nasal cavity, papillary tumours of the trachea, hepatocellular adenomas and local fibrosarcomas in hamsters.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. N-Nitrosodiethanolamine has been found in variable concentrations in tobacco, one pesticide formation, some cosmetic preparations and, in much higher concentrations (0.02-3%), in cutting fluids. These reports should permit the identification of exposed groups.

5.3 Evaluation

There is sufficient evidence of a carcinogenic effect of N-nitrosodiethanolamine in two experimental animal species. In view of the widespread exposure to appreciable concentrations of N-nitrosodiethanolamine, efforts should be made to obtain epidemiological information. Although no epidemiological data were available, N-nitrosodiethanolamine should be regarded for practical purposes as if it were carcinogenic to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B); Vol. 77 (2000)

For definition of terms, see Preamble Evaluation.

Synonyms

Diethanolnitrosamine
NDELA
N-Nitroso-bis(2-hydroxyethyl)amine
Nitrosoimino diethanol

Last updated: 25 March 1998





























    See Also:
       Toxicological Abbreviations
       Nitrosodiethanolamine, n-  (IARC Summary & Evaluation, Volume 77, 2000)