International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 17 (1978) (p. 221)

CAS No.: 10595-95-6
Chem. Abstr. Name: N-Methyl-N-nitroso-ethamine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosomethylethylamine is carcinogenic in rats after its oral administration, the only species and route tested: it produces hepatocellular carcinomas.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Available information on occurrence suggests that the general population may be exposed sporadically to low levels of N-nitrosomethylethylamine; however, no exposed group suitable for an epidemiological investigation has yet been identified. Reports suggest that tobacco smokers way be exposed to N-nitrosomthylethylamine together with other N-nitroso compounds.

5.3 Evaluation

There is sufficient evidence of a carcinogenic effect of N-nitrosomethylethylamine in one experimental animal species. No epidemiological data were available.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)

For definition of terms, see Preamble Evaluation.


Last updated: 27 March 1998

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