International Agency for Research on Cancer (IARC) - Summaries & Evaluations
N-NITROSOMETHYLVINYLAMINE
VOL.: 17 (1978) (p. 257)
CAS No.: 4549-40-0
Chem. Abstr. Name: Name: N-Methyl-N-nitroso-ethenylamine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
N-Nitrosomethylvinylamine is carcinogenic in rats, the only species
tested. It produces carcinomas of the oesophagus, tongue and pharynx
after its continuous oral administration and carcinomas of the nasal
cavities after inhalation exposure.
5.2 Human data
No case reports or epidemiological studies were available to the
Working Group. Insufficient information on the occurrence or use of
this compound was available to permit identification of exposed
groups.
5.3 Evaluation
There is sufficient evidence of a carcinogenic effect of
N-nitrosomethylvinylamine in one experimental animal species. Although
no epidemiological data were available, N-nitrosomethylvinylamine
should be regarded for practical purposes as if it were carcinogenic
to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)
For definition of terms, see Preamble Evaluation.
Synonyms
- N-Methyl-N-nitrosovinylamine
- Methylvinylnitrosamine
- NMVA
Last updated: 27 March 1998