International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 17 (1978) (p. 257)

CAS No.: 4549-40-0
Chem. Abstr. Name: Name: N-Methyl-N-nitroso-ethenylamine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosomethylvinylamine is carcinogenic in rats, the only species tested. It produces carcinomas of the oesophagus, tongue and pharynx after its continuous oral administration and carcinomas of the nasal cavities after inhalation exposure.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Insufficient information on the occurrence or use of this compound was available to permit identification of exposed groups.

5.3 Evaluation

There is sufficient evidence of a carcinogenic effect of N-nitrosomethylvinylamine in one experimental animal species. Although no epidemiological data were available, N-nitrosomethylvinylamine should be regarded for practical purposes as if it were carcinogenic to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)

For definition of terms, see Preamble Evaluation.


Last updated: 27 March 1998

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