International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 17 (1978) (p. 263)

CAS No.: 59-89-2
Chem. Abstr. Name: 4-Nitrosomorpholine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosomorpholine is carcinogenic in mice, rats, Syrian golden, Chinese and European hamsters and various fish. Following its oral administration, it produces benign and malignant tumours of the liver and lung in mice, of the liver, kidney and blood vessels in rats and of the liver in hamsters. After its subcutaneous injection it produces tumours of the upper digestive and respiratory tracts in hamsters; it is carcinogenic after its administration in single doses. It produces liver tumours in rats following its intravenous injection. It produces liver tumours in various fish following its administration in tank-water. A study in hamsters has been reported in which a dose-response relationship was established.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Insufficient information on the occurrence of N-nitrosomorpholine was available to permit identification of exposed groups.

5.3 Evaluation

There is sufficient evidence for a carcinogenic effect of N-nitrosomorpholine in several experimental animal species. Although no epidemiological data were available, N-nitrosomorpholine should be regarded for practical purposes as if it were carcinogenic to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)

For definition of terms, see Preamble Evaluation.


Last updated: 27 March 1998

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